Effect of Organic Solvents on a Production of PLGA-Based Drug- Loaded Nanoparticles Using a Microfluidic Device

Bao, Yi; Maeki, Masatoshi; Ishida, Akihiko; Tani, Hirofumi; Tokeshi, Manabu

Effect of Organic Solvents on a Production of PLGA-Based Drug- Loaded Nanoparticles Using a Microfluidic Device

Bao, Yi; Maeki, Masatoshi; Ishida, Akihiko et al.

ACS Omega, 2022, 7(37), 33079-33086

Permalink : https://hdl.handle.net/2115/87275

このアイテムのアクセス数:295件（2026-01-23 08:26 集計）

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ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1021/acsomega.2c03137			4

論文情報

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/87275
タイトル	Effect of Organic Solvents on a Production of PLGA-Based Drug- Loaded Nanoparticles Using a Microfluidic Device
著者	Bao, Yi ; Maeki, Masatoshi ; Ishida, Akihiko ; Tani, Hirofumi ; Tokeshi, Manabu
著者名 Bao, Yi
著者名 Maeki, Masatoshi
e-Rad_Researcher 20312382 著者名 Ishida, Akihiko
e-Rad_Researcher 10271644 著者名 Tani, Hirofumi
e-Rad_Researcher 60311437 著者名 Tokeshi, Manabu
言語	英語
キーワード	Amorphous materials
	Copolymers
	Encapsulation
	Microfluidic devices
	Solvents
発行日	2022-09-06
出版者	American Chemical Society
収録物名	ACS Omega
巻(号)	7(37)
ページ	33079-33086
抄録	The translation of nanoparticles (NPs) from laboratory to clinical settings is limited, which is not ideal. One of the reasons for this is that we currently have limited ability to precisely regulate various physicochemical parameters of nanoparticles. This has made it difficult to rapidly perform targeted screening of drug preparation conditions. In this study, we attempted to broaden the range of preparation conditions for particle size-modulated poly(lactic-co-glycolic-acid) (PLGA) NP to enhance their applicability for drug delivery systems (DDS). This was done using a variety of organic solvents and a glass-based microfluidic device. Furthermore, we compared the PDMS-based microfluidic device to the glass-based microfluidic device in terms of the possibility of a wider range of preparation conditions, especially the effect of different solvents on the size of the PLGA NPs. PLGA NPs with different sizes (sub-200 nm) were successfully prepared, and three different types of taxanes were employed for encapsulation. The drug-loaded NPs showed size-dependent cytotoxicity in cellular assays, regardless of the taxane drug used.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2470-1343
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1021/acsomega.2c03137