l-Carnitine supplementation for the prevention of postoperative atrial fibrillation in aortic valve surgery

Shingu, Yasushige; Katoh, Nobuyasu; Ooka, Tomonori et al.

General thoracic and cardiovascular surgery, 2021, 69(11), 1460-1466

Permalink : https://hdl.handle.net/2115/87317

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アクセス権
open access
URI
https://hdl.handle.net/2115/87317
タイトル
l-Carnitine supplementation for the prevention of postoperative atrial fibrillation in aortic valve surgery
著者
Shingu, Yasushige ; Katoh, Nobuyasu ; Ooka, Tomonori ; Katoh, Hiroki ; Wakasa, Satoru
e-Rad_Researcher
30617064
著者名
Shingu, Yasushige
著者名
Katoh, Nobuyasu
著者名
Ooka, Tomonori
著者名
Katoh, Hiroki
e-Rad_Researcher
10374365
著者名
Wakasa, Satoru
言語
英語
キーワード
Postoperative atrial fibrillation
l-Carnitine
Aortic valve surgery
発行日
2021-11-01
出版者
Springer
収録物名
General thoracic and cardiovascular surgery
巻(号)
69(11)
ページ
1460-1466
抄録
Objectives l-Carnitine, a quaternary amine, improves fatty acid metabolism in the heart and has anti-inflammatory effects. Several studies have reported the efficacy of l-carnitine for the prophylaxis of arrhythmia. We assessed the clinical effectiveness of l-carnitine in preventing postoperative atrial fibrillation (POAF) in aortic valve surgery. Methods Thirty patients who underwent aortic valve surgery were included. Fifteen patients had no prophylaxis other than conventional measures (control), while 15 patients received oral l-carnitine for 9 days (daily dose of 3 g). The incidence of POAF during 1 week after surgery was compared between the two groups. The multivariable logistic regression analysis for POAF was performed using the pre- and intraoperative parameters. Results Preoperative characteristics and operative data were comparable between the groups. The POAF rate was significantly lower in the l-carnitine group than in the control (20% and 60%, respectively; P = 0.025). l-Carnitine use was an independently negative predictor for POAF (odds ratio 0.067; 95% confidence interval 0.006-0.768). Conclusions l-Carnitine administration may have potential for the prevention of POAF in aortic valve surgery.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is a post-peer-review, pre-copyedit version of an article published in General thoracic and cardiovascular surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-021-01616-2
PISSN
1863-6705
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s11748-021-01616-2