Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine

Endo, Tsutomu; Imagama, Shiro; Kato, Satoshi; Kaito, Takashi; Sakai, Hiroaki; Ikegawa, Shiro; Kawaguchi, Yoshiharu; Kanayama, Masahiro; Hisada, Yuichiro; Koike, Yoshinao; Ando, Kei; Kobayashi, Kazuyoshi; Oda, Itaru; Okada, Kazufumi; Takagi, Ryo; Iwasaki, Norimasa; Takahata, Masahiko

Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine

Endo, Tsutomu; Imagama, Shiro; Kato, Satoshi et al.

Global Spine Journal, 2022, 12(8), 1770-1780

Permalink : https://hdl.handle.net/2115/87323

このアイテムのアクセス数:361件（2026-07-21 19:25 集計）

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https://doi.org/10.1177/2192568221989300			19

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アクセス権	open access
URI	https://hdl.handle.net/2115/87323
タイトル	Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine
著者	Endo, Tsutomu ; Imagama, Shiro ; Kato, Satoshi ; Kaito, Takashi ; Sakai, Hiroaki ; Ikegawa, Shiro ; Kawaguchi, Yoshiharu ; Kanayama, Masahiro ; Hisada, Yuichiro ; Koike, Yoshinao ; Ando, Kei ; Kobayashi, Kazuyoshi ; Oda, Itaru ; Okada, Kazufumi ; Takagi, Ryo ; Iwasaki, Norimasa ; Takahata, Masahiko
著者名 Endo, Tsutomu
著者名 Imagama, Shiro
著者名 Kato, Satoshi
著者名 Kaito, Takashi
著者名 Sakai, Hiroaki
著者名 Ikegawa, Shiro
著者名 Kawaguchi, Yoshiharu
著者名 Kanayama, Masahiro
著者名 Hisada, Yuichiro
著者名 Koike, Yoshinao
著者名 Ando, Kei
著者名 Kobayashi, Kazuyoshi
著者名 Oda, Itaru
著者名 Okada, Kazufumi
著者名 Takagi, Ryo
著者名 Iwasaki, Norimasa
e-Rad_Researcher 40374368 著者名 Takahata, Masahiko
言語	英語
キーワード	vitamin A
	vitamin B6
	dietary habits
	severe obesity
	early-onset OPLL
	heterotopic ossification
発行日	2022-10
出版者	SAGE Publications
収録物名	Global Spine Journal
巻(号)	12(8)
ページ	1770-1780
抄録	Study Design: A sex- and age-matched case-control study and a cross-sectional study. Objective: In our previous study, patients with early-onset (<50 years of age) ossification of the posterior longitudinal ligament (OPLL) had distinct features such as morbid obesity, a high prevalence of lifestyle-related diseases, and diffuse ossified lesions mainly affecting the thoracic spine. Our goals were to determine whether early-onset OPLL patients have unbalanced dietary habits and to identify nutritional factors associated with OPLL exacerbation. Methods: In Study 1, the simple brief-type self-administered diet history questionnaire (BDHQ) was used to compare nutrient intake levels of early-onset OPLL patients (n = 13) with those of sex- and age-matched non-OPLL controls (n = 39) or with those of common OPLL (onset age >= 50 years, n = 62). In Study 2, serological validation was conducted for thoracic OPLL patients (n = 77) and non-OPLL controls (n = 101) in a nationwide multicenter study in Japan. Results: The BDHQ showed that the early-onset OPLL patients had significantly lower intakes of vitamins A and B6 than non-OPLL controls. These results were validated by lower serum vitamins A and B6 levels in the early-onset thoracic OPLL patients. The severity of OPLL negatively correlated with serum vitamin A levels in male early-onset OPLL patients. The multiple regression analysis revealed that the severity of thoracic OPLL had an association with onset age and serum vitamin A level. Conclusions: Vitamin A deficiency resulting from unbalanced dietary habits is associated with exacerbation of male early-onset OPLL.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2192-5682
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1177/2192568221989300