Specific Gene Duplication and Loss of Cytochrome P450 in Families 1-3 in Carnivora (Mammalia, Laurasiatheria)

Kondo, Mitsuki; Ikenaka, Yoshinori; Nakayama, Shouta M. M.; Kawai, Yusuke K.; Ishizuka, Mayumi

Specific Gene Duplication and Loss of Cytochrome P450 in Families 1-3 in Carnivora (Mammalia, Laurasiatheria)

Kondo, Mitsuki; Ikenaka, Yoshinori; Nakayama, Shouta M. M. et al.

Animals, 2022, 12(20), 2821

Permalink : https://hdl.handle.net/2115/87329

このアイテムのアクセス数:291件（2026-01-20 02:46 集計）

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https://doi.org/10.3390/ani12202821

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/87329
タイトル	Specific Gene Duplication and Loss of Cytochrome P450 in Families 1-3 in Carnivora (Mammalia, Laurasiatheria)
著者	Kondo, Mitsuki ; Ikenaka, Yoshinori ; Nakayama, Shouta M. M. ; Kawai, Yusuke K. ; Ishizuka, Mayumi
著者名 Kondo, Mitsuki
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
著者名 Kawai, Yusuke K.
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	cytochrome P450
	genome database
	in silico analysis
	phase I metabolism
	wildlife
	xenobiotic metabolism
発行日	2022-10-18
出版者	MDPI
収録物名	Animals
巻(号)	12(20)
ページ	2821
抄録	Cytochrome P450s are among the most important xenobiotic metabolism enzymes that catalyze the metabolism of a wide range of chemicals. Through duplication and loss events, CYPs have created their original feature of detoxification in each mammal. We performed a comprehensive genomic analysis to reveal the evolutionary features of the main xenobiotic metabolizing family: the CYP1-3 families in Carnivora. We found specific gene expansion of CYP2Cs and CYP3As in omnivorous animals, such as the brown bear, the black bear, the dog, and the badger, revealing their daily phytochemical intake as providing the causes of their evolutionary adaptation. Further phylogenetic analysis of CYP2Cs revealed Carnivora CYP2Cs were divided into CYP2C21, 2C41, and 2C23 orthologs. Additionally, CYP3As phylogeny also revealed the 3As' evolution was completely different to that of the Caniformia and Feliformia taxa. These studies provide us with fundamental genetic and evolutionary information on CYPs in Carnivora, which is essential for the appropriate interpretation and extrapolation of pharmacokinetics or toxicokinetic data from experimental mammals to wild Carnivora.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2076-2615
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ani12202821