Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003–2011

Okada, Emiko; Kashino, Ikuko; Matsuura, Hideyuki; Sasaki, Seiko; Miyashita, Chihiro; Yamamoto, Jun; Ikeno, Tamiko; Ito, Yoichi M.; Matsumura, Toru; Tamakoshi, Akiko; Kishi, Reiko

Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003–2011

Okada, Emiko; Kashino, Ikuko; Matsuura, Hideyuki et al.

Environment International, 2013, 60, 89-96

Permalink : https://hdl.handle.net/2115/87332

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アクセス権	open access
URI	https://hdl.handle.net/2115/87332
タイトル	Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003–2011
著者	Okada, Emiko ; Kashino, Ikuko ; Matsuura, Hideyuki ; Sasaki, Seiko ; Miyashita, Chihiro ; Yamamoto, Jun ; Ikeno, Tamiko ; Ito, Yoichi M. ; Matsumura, Toru ; Tamakoshi, Akiko ; Kishi, Reiko
著者名 Okada, Emiko
著者名 Kashino, Ikuko
著者名 Matsuura, Hideyuki
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Yamamoto, Jun
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
著者名 Matsumura, Toru
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Perfluorooctane sulfonate
	Perfluorooctanoic acid
	Perfluorononanoic acid
	Perfluorodecanoic aci
	Human maternal plasma
	Temporal trend
発行日	2013-10-01
出版者	Elsevier
収録物名	Environment International
巻(号)	60
ページ	89-96
抄録	Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that are used in a wide range of consumer products. Recent epidemiological studies have shown that prenatal exposure to toxic levels of PFAAs in the environment may adversely affect fetal growth and humoral immune response in infants and children. Here we have characterized levels of prenatal exposure to PFAA between 2003 and 2011 in Hokkaido, Japan, by measuring PFAA concentrations in plasma samples from pregnant women. The study population comprised 150 women who enrolled in a prospective birth cohort study conducted in Hokkaido. Eleven PFAAs were measured in maternal plasma samples using simultaneous analysis by ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. At the end of the study, in 2011, age- and parity-adjusted mean concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), perfluorotridecanoic acid (PFTrDA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS) were 1.35ng/mL, 1.26ng/mL, 0.66ng/mL, 1.29ng/mL, 0.25ng/mL, 0.33ng/mL, 0.28ng/mL, and 3.86ng/mL, respectively. Whereas PFOS and PFOA concentrations declined 8.4%/y and 3.1%/y, respectively, PFNA and PFDA levels increased 4.7%/y and 2.4%/y, respectively, between 2003 and 2011. PFUnDA, PFDoDA, and PFTrDA were detected in the vast majority of maternal samples, but no significant temporal trend was apparent. Future studies must involve a larger population of pregnant women and their children to determine the effects of prenatal exposure to PFAA on health outcomes in infants and children.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0160-4120
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.envint.2013.07.013