Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size

Miyashita, Chihiro; Sasaki, Seiko; Ikeno, Tamiko; Araki, Atsuko; Ito, Sachiko; Kajiwara, Jumboku; Todaka, Takashi; Hachiya, Noriyuki; Yasutake, Akira; Murata, Katsuyuki; Nakajima, Tamie; Kishi, Reiko

Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size

Miyashita, Chihiro; Sasaki, Seiko; Ikeno, Tamiko et al.

Science of The Total Environment, 2015, 533, 256-265

Permalink : https://hdl.handle.net/2115/87336

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アクセス権	open access
URI	https://hdl.handle.net/2115/87336
タイトル	Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size
著者	Miyashita, Chihiro ; Sasaki, Seiko ; Ikeno, Tamiko ; Araki, Atsuko ; Ito, Sachiko ; Kajiwara, Jumboku ; Todaka, Takashi ; Hachiya, Noriyuki ; Yasutake, Akira ; Murata, Katsuyuki ; Nakajima, Tamie ; Kishi, Reiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Sasaki, Seiko
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 90580936 著者名 Ito, Sachiko
著者名 Kajiwara, Jumboku
著者名 Todaka, Takashi
著者名 Hachiya, Noriyuki
著者名 Yasutake, Akira
著者名 Murata, Katsuyuki
著者名 Nakajima, Tamie
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Polychlorinated biphenyls
	Methylmercury
	Birth size
	Small for gestational age
	In utero exposure
	Polyunsaturated fatty acids
発行日	2015-11-15
出版者	Elsevier
収録物名	Science of The Total Environment
巻(号)	533
ページ	256-265
抄録	The adverse effects of in utero exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg), and the beneficial effects of nutrients from maternal fish intake might have opposing influences on fetal growth. In this study, we assessed the effects of in utero exposure to PCBs and MeHg on birth size in the Japanese population, which is known to have a high frequency of fish consumption. The concentrations of PCBs and polyunsaturated fatty acids in maternal blood, and the total mercury in hair (as a biomarker of MeHg exposure) were measured during pregnancy and at delivery. Maternal intakes of fish (subtypes: fatty and lean) and shellfishes were calculated from a food frequency questionnaire administered at delivery. Newborn anthropometric measurement data were obtained from birth records. The associations between chemical exposures and birth size were analyzed by using multiple regression analysis with adjustment for confounding factors among 367 mother–newborn pairs. The birth weight was 3073 ± 37 g (mean ± SD). The incidence of babies small for gestational age (SGA) by weight was 4.9%. The median concentrations of total PCBs and hair mercury were 108 ng/g lipid and 1.41 μg/g, respectively. There was no overall association between mercury concentrations and birth weight, birth length, chest circumference, and head circumference. We observed that the risk of SGA by weight decreased with increasing mercury concentration in regression analyses with adjustment for polyunsaturated fatty acids. Our results suggest that the beneficial effect of essential nutrition may mask the adverse effects of MeHg on birth size. The concentrations of PCBs had no association with birth size.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0048-9697
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.scitotenv.2015.06.108