Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children

Mitsui, Takahiko; Araki, Atsuko; Goudarzi, Houman; Miyashita, Chihiro; Ito, Sachiko; Sasaki, Seiko; Kitta, Takeya; Moriya, Kimihiko; Cho, Kazutoshi; Morioka, Keita; Kishi, Reiko; Shinohara, Nobuo; Takeda, Masayuki; Nonomura, Katsuya

Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children

Mitsui, Takahiko; Araki, Atsuko; Goudarzi, Houman et al.

Steroids, 2016, 113, 46-51

Permalink : https://hdl.handle.net/2115/87337

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アクセス権	open access
URI	https://hdl.handle.net/2115/87337
タイトル	Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children
著者	Mitsui, Takahiko ; Araki, Atsuko ; Goudarzi, Houman ; Miyashita, Chihiro ; Ito, Sachiko ; Sasaki, Seiko ; Kitta, Takeya ; Moriya, Kimihiko ; Cho, Kazutoshi ; Morioka, Keita ; Kishi, Reiko ; Shinohara, Nobuo ; Takeda, Masayuki ; Nonomura, Katsuya
著者名 Mitsui, Takahiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
著者名 Goudarzi, Houman
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 90580936 著者名 Ito, Sachiko
著者名 Sasaki, Seiko
著者名 Kitta, Takeya
著者名 Moriya, Kimihiko
e-Rad_Researcher 10312365 著者名 Cho, Kazutoshi
著者名 Morioka, Keita
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
e-Rad_Researcher 90250422 著者名 Shinohara, Nobuo
著者名 Takeda, Masayuki
e-Rad_Researcher 60113750 著者名 Nonomura, Katsuya
言語	英語
キーワード	2D/4D
	DHEA
	Prenatal
	Adrenal
	Androgen
	Sex differentiation
発行日	2016-09
出版者	Elsevier
収録物名	Steroids
巻(号)	113
ページ	46-51
抄録	Objectives We investigated the relationship between the levels of adrenal steroid hormones in cord blood and the second to fourth digit ratio (2D/4D), which is regarded as an indirect method to investigate the putative effects of prenatal exposure to androgens, in school-aged children. Materials and methods Of the 514 mother-child pairs who participated in the prospective cohort study of birth in Sapporo between 2002 and 2005, the following adrenal steroid hormone levels in 294 stored cord blood samples (135 males and 159 females) were measured; cortisol, cortisone, androstenedione and dehydroepiandrosterone (DHEA). A total of 190 out of 350 children who were currently school-aged and contactable for this survey sent back photocopies of their palms for 2D/4D measurements. Results 2D/4D in all right hands, left hands, and mean values was significantly lower in males than in females (p < 0.01). DHEA levels were significantly higher in females. A multivariate regression model showed that 2D/4D negatively correlated with DHEA in males only (p < 0.01). No correlations were observed in the other adrenal steroid hormones tested in males or in any adrenal steroid hormones in females. Conclusion DHEA is mainly secreted in large amounts by the adrenal gland and is transformed into active sex-steroid hormones in peripheral tissues. The present study demonstrated that sex differences in digits were influenced by adrenal androgens during the prenatal period, possibly through intracrinological processes for androgen receptors located in fetal cartilaginous tissues.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0039-128X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.steroids.2016.06.009