Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study

Kobayashi, Sumitaka; Sata, Fumihiro; Ikeda-Araki, Atsuko; Miyashita, Chihiro; Itoh, Sachiko; Goudarzi, Houman; Iwasaki, Yusuke; Mitsui, Takahiko; Moriya, Kimihiko; Shinohara, Nobuo; Cho, Kazutoshi; Kishi, Reiko

Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study

Kobayashi, Sumitaka; Sata, Fumihiro; Ikeda-Araki, Atsuko et al.

Reproductive toxicology, 2021, 105, 221-231

Permalink : https://hdl.handle.net/2115/87341

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アクセス権	open access
URI	https://hdl.handle.net/2115/87341
タイトル	Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study
著者	Kobayashi, Sumitaka ; Sata, Fumihiro ; Ikeda-Araki, Atsuko ; Miyashita, Chihiro ; Itoh, Sachiko ; Goudarzi, Houman ; Iwasaki, Yusuke ; Mitsui, Takahiko ; Moriya, Kimihiko ; Shinohara, Nobuo ; Cho, Kazutoshi ; Kishi, Reiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Sata, Fumihiro
e-Rad_Researcher 00619885 著者名 Ikeda-Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
著者名 Goudarzi, Houman
著者名 Iwasaki, Yusuke
著者名 Mitsui, Takahiko
著者名 Moriya, Kimihiko
e-Rad_Researcher 90250422 著者名 Shinohara, Nobuo
e-Rad_Researcher 10312365 著者名 Cho, Kazutoshi
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Perfluoroalkyl substances
	Genotype
	Sex hormone
	Gene-environment interaction
	Sex difference
発行日	2021-10
出版者	Elsevier
収録物名	Reproductive toxicology
巻(号)	105
ページ	221-231
抄録	Prenatal sex hormones affect fetal growth; for example, prenatal exposure to low levels of androgen accelerates female puberty onset. We assessed the association of perfluoroalkyl substances (PFASs) in maternal sera and infant genotypes of genes encoding enzymes involved in sex steroid hormone biosynthesis on cord sera sex hormone levels in a prospective birth cohort study of healthy pregnant Japanese women (n = 224) recruited in Sapporo between July 2002 and October 2005. We analyzed PFAS and five sex hormone levels using liquid chromatography-tandem mass spectrometry. Cytochrome P450 (CYP) 17A1 (CYP17A1 rs743572), 19A1 (CYP19A1 rs10046, rs700519, and rs727479), 3 beta-hydroxysteroid dehydrogenase type 1 (HSD3B1 rs6203), type 2 (HSD3B2 rs1819698, rs2854964, and rs4659175), 17 beta-hydroxysteroid dehydrogenase type 1 (HSD17B1 rs605059, rs676387, and rs2676531), and type 3 (HSD17B3 rs4743709) were analyzed using real-time PCR. Multiple linear regression models were used to establish the influence of log10-transformed PFAS levels and infant genotypes on log10-transformed sex steroid hormone levels. When the interaction between perfluorooctanesulfonate (PFOS) levels and female infant genotype CYP17A1 (rs743572) on the androstenedione (A-dione) levels was considered, the estimated changes (95 % confidence intervals) in A-dione levels against PFOS levels, female infant genotype CYP17A1 (rs743572)-AG/GG, and interaction between them showed a mean increase of 0.445 (0.102, 0.787), mean increase of 0.392 (0.084, 0.707), and mean reduction of 0.579 (0.161, 0.997) (Pint = 0.007), respectively. Moreover, a female-specific interaction with testosterone levels was observed. A-dione and T levels showed positive main effects and negative interaction with PFOS levels and the female infant CYP17A1 genotype.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0890-6238
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.reprotox.2021.09.003