Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome

Saito, Rika; Kawamoto, Yasuyuki; Nishida, Mutsumi; Iwai, Takahito; Kikuchi, Yasuka; Yokota, Isao; Takagi, Ryo; Yamamura, Takahiro; Ito, Ken; Harada, Kazuaki; Yuki, Satoshi; Komatsu, Yoshito; Sakamoto, Naoya

Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome

Saito, Rika; Kawamoto, Yasuyuki; Nishida, Mutsumi et al.

International journal of clinical oncology, 2022, 27(11), 1780-1790

Permalink : https://hdl.handle.net/2115/87344

このアイテムのアクセス数:388件（2026-01-13 09:19 集計）

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https://doi.org/10.1007/s10147-022-02235-4

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/87344
タイトル	Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome
著者	Saito, Rika ; Kawamoto, Yasuyuki ; Nishida, Mutsumi ; Iwai, Takahito ; Kikuchi, Yasuka ; Yokota, Isao ; Takagi, Ryo ; Yamamura, Takahiro ; Ito, Ken ; Harada, Kazuaki ; Yuki, Satoshi ; Komatsu, Yoshito ; Sakamoto, Naoya
著者名 Saito, Rika
e-Rad_Researcher 60755601 著者名 Kawamoto, Yasuyuki
著者名 Nishida, Mutsumi
著者名 Iwai, Takahito
著者名 Kikuchi, Yasuka
著者名 Yokota, Isao
著者名 Takagi, Ryo
著者名 Yamamura, Takahiro
著者名 Ito, Ken
著者名 Harada, Kazuaki
著者名 Yuki, Satoshi
e-Rad_Researcher 60333598 著者名 Komatsu, Yoshito
e-Rad_Researcher 10334418 著者名 Sakamoto, Naoya
言語	英語
キーワード	Ultrasonography
	Liver stiffness measurement
	Shear-wave elastography
	Oxaliplatin
	Sinusoidal obstruction syndrome
発行日	2022-08-30
出版者	Springer
収録物名	International journal of clinical oncology
巻(号)	27(11)
ページ	1780-1790
抄録	Background Sinusoidal obstruction syndrome (SOS) refers to liver injury caused by hematopoietic stem cell transplantation (HSCT) and anticancer drugs including oxaliplatin. Increased splenic volume (SV) on computed tomography (CT) indicates oxaliplatin-induced SOS. Similarly, ultrasonography and liver stiffness measurement (LSM) by shear-wave elastography (SWE) can help diagnose SOS after HSCT; however, their usefulness for diagnosing oxaliplatin-induced SOS remains unclear. We investigated the usefulness of the Hokkaido ultrasonography-based scoring system with 10 ultrasonographic parameters (HokUS-10) and SWE in diagnosing oxaliplatin-induced SOS early. Methods In this prospective observational study, ultrasonography and SWE were performed before and at 2, 4, and 6 months after oxaliplatin-based chemotherapy. HokUS-10 was used for assessment. CT volumetry of the SV was performed in clinical practice, and an SV increase >= 30% was considered the diagnostic indicator of oxaliplatin-induced SOS. We assessed whether HokUS-10 and SWE can lead to an early detection of oxaliplatin-induced SOS before an increased SV on CT. Results Of the 30 enrolled patients with gastrointestinal cancers, 12 (40.0%) with an SV increase >= 30% on CT were diagnosed with SOS. The HokUS-10 score was not correlated with an SV increase >= 30% (r = 0.18). The change in rate of three HokUS-10 parameters were correlated with an SV increase >= 30% (r = 0.32-0.41). The change in rate of LSM by SWE was correlated with an SV increase >= 30% (r = 0.40). Conclusions The usefulness of HokUS-10 score was not demonstrated; however, some HokUS-10 parameters and SWE could be useful for the early diagnosis of oxaliplatin-induced SOS.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1341-9625
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1007/s10147-022-02235-4