Appropriate Lymph Node Dissection Sites for Cancer in the Body and Tail of the Pancreas : A Multicenter Retrospective Study

Tanaka, Kimitaka; Kimura, Yasutoshi; Hayashi, Tsuyoshi; Ambo, Yoshiyasu; Yoshida, Makoto; Umemoto, Kazufumi; Murakami, Takeshi; Asano, Toshimichi; Nakamura, Toru; Hirano, Satoshi

Appropriate Lymph Node Dissection Sites for Cancer in the Body and Tail of the Pancreas : A Multicenter Retrospective Study

Tanaka, Kimitaka; Kimura, Yasutoshi; Hayashi, Tsuyoshi et al.

Cancers, 2022, 14(18), 4409

Permalink : https://hdl.handle.net/2115/87347

このアイテムのアクセス数:449件（2026-08-13 12:16 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.3390/cancers14184409			92

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/87347
タイトル	Appropriate Lymph Node Dissection Sites for Cancer in the Body and Tail of the Pancreas : A Multicenter Retrospective Study
著者	Tanaka, Kimitaka ; Kimura, Yasutoshi ; Hayashi, Tsuyoshi ; Ambo, Yoshiyasu ; Yoshida, Makoto ; Umemoto, Kazufumi ; Murakami, Takeshi ; Asano, Toshimichi ; Nakamura, Toru ; Hirano, Satoshi
e-Rad_Researcher 10758642 著者名 Tanaka, Kimitaka
著者名 Kimura, Yasutoshi
著者名 Hayashi, Tsuyoshi
著者名 Ambo, Yoshiyasu
著者名 Yoshida, Makoto
著者名 Umemoto, Kazufumi
著者名 Murakami, Takeshi
著者名 Asano, Toshimichi
著者名 Nakamura, Toru
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
言語	英語
キーワード	pancreatic cancer
	distal pancreatectomy
	lymph node metastasis
	spleen preservation
	efficacy index
発行日	2022-09
出版者	MDPI
収録物名	Cancers
巻(号)	14(18)
ページ	4409
抄録	Simple Summary Distal pancreatectomy has become the standard surgery for patients with pancreatic body-tail cancers. The optimal area for dissection remains controversial, and there is an emphasis on preserving as much tissue as possible while eradicating the cancer. This multicenter, retrospective study evaluated the frequency and patterns of lymph node metastasis based on tumor site among 235 patients with pancreatic body-tail cancers to determine the optimal lymph node dissection area for distal pancreatectomy. Patients with pancreatic body cancer tumors showed no metastasis to the splenic hilum lymph node. Spleen-preserving pancreatectomy might be feasible for Pb cancer. Distal pancreatectomy (DP) with lymphadenectomy is the standard surgery for pancreatic body-tail cancer. However, the optimal lymph node (LN) dissection area for DP remains controversial. Thus, we evaluated the frequency and patterns of LN metastasis based on the tumor site. In this multicenter retrospective study, we examined 235 patients who underwent DP for pancreatic cancer. Tumor sites were classified as confined to the pancreatic body (Pb) or pancreatic tail (Pt). The efficacy index (EI) was calculated by multiplying the frequency of metastasis to each LN station by the five-year survival rate of patients with metastasis to that station. LN metastasis occurred in 132/235 (56.2%) of the patients. Patients with Pb tumors showed no metastasis to the splenic hilum LN. Distal splenic artery LNs and anterosuperior/posterior common hepatic artery LNs did not benefit from dissection for Pb and Pt tumors, respectively. In multivariate analysis, splenic artery LN metastasis was identified as an independent predictor of poor overall survival in patients with pancreatic body-tail cancer. In conclusion, differences in metastatic LN sites were evident in pancreatic body-tail cancers confined to the Pb or Pt. Spleen-preserving pancreatectomy might be feasible for Pb cancer.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/cancers14184409