ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons

Hasebe, Rie; Murakami, Kaoru; Harada, Masaya; Halaka, Nada; Nakagawa, Hiroshi; Kawano, Fuminori; Ohira, Yoshinobu; Kawamoto, Tadafumi; Yull, Fiona E. E.; Blackwell, Timothy S. S.; Nio-Kobayashi, Junko; Iwanaga, Toshihiko; Watanabe, Masahiko; Watanabe, Nobuhiro; Hotta, Harumi; Yamashita, Toshihide; Kamimura, Daisuke; Tanaka, Yuki; Murakami, Masaaki

ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons

Hasebe, Rie; Murakami, Kaoru; Harada, Masaya et al.

Journal of experimental medicine, 2022, 219(6), e20212019

Permalink : https://hdl.handle.net/2115/87375

このアイテムのアクセス数:1,018件（2026-01-14 22:28 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
JEM 219(6) e20212019	pdf	7.03 MB	244

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/87375
タイトル	ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons
著者	Hasebe, Rie ; Murakami, Kaoru ; Harada, Masaya ; Halaka, Nada ; Nakagawa, Hiroshi ; Kawano, Fuminori ; Ohira, Yoshinobu ; Kawamoto, Tadafumi ; Yull, Fiona E. E. ; Blackwell, Timothy S. S. ; Nio-Kobayashi, Junko ; Iwanaga, Toshihiko ; Watanabe, Masahiko ; Watanabe, Nobuhiro ; Hotta, Harumi ; Yamashita, Toshihide ; Kamimura, Daisuke ; Tanaka, Yuki ; Murakami, Masaaki
著者名 Hasebe, Rie
著者名 Murakami, Kaoru
著者名 Harada, Masaya
著者名 Halaka, Nada
著者名 Nakagawa, Hiroshi
著者名 Kawano, Fuminori
著者名 Ohira, Yoshinobu
著者名 Kawamoto, Tadafumi
著者名 Yull, Fiona E. E.
著者名 Blackwell, Timothy S. S.
著者名 Nio-Kobayashi, Junko
著者名 Iwanaga, Toshihiko
著者名 Watanabe, Masahiko
著者名 Watanabe, Nobuhiro
著者名 Hotta, Harumi
著者名 Yamashita, Toshihide
著者名 Kamimura, Daisuke
著者名 Tanaka, Yuki
e-Rad_Researcher 00250514 著者名 Murakami, Masaaki
言語	英語
キーワード	Innate immunity and inflammation
キーワード	Neuroscience
発行日	2022-06-06
出版者	Rockefeller University Press
収録物名	Journal of experimental medicine
巻(号)	219(6)
ページ	e20212019
抄録	Neural circuits between lesions are one mechanism through which local inflammation spreads to remote positions. Here, we show the inflammatory signal on one side of the joint is spread to the other side via sensory neuron–interneuron crosstalk, with ATP at the core. Surgical ablation or pharmacological inhibition of this neural pathway prevented inflammation development on the other side. Mechanistic analysis showed that ATP serves as both a neurotransmitter and an inflammation enhancer, thus acting as an intermediary between the local inflammation and neural pathway that induces inflammation on the other side. These results suggest blockade of this neural pathway, which is named the remote inflammation gateway reflex, may have therapeutic value for inflammatory diseases, particularly those, such as rheumatoid arthritis, in which inflammation spreads to remote positions.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	©2022 Hasebe et al. Originally published in Journal of experimental medicine. https://doi.org/10.1084/jem.20212019
PISSN	0022-1007
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1084/jem.20212019