Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire : A prospective birth cohort

Kobayashi, Sumitaka; Itoh, Sachiko; Miyashita, Chihiro; Bamai, Yu Ait; Yamaguchi, Takeshi; Masuda, Hideyuki; Itoh, Mariko; Yamazaki, Keiko; Tamura, Naomi; Hanley, Sharon J. B.; Ikeda-Araki, Atsuko; Saijo, Yasuaki; Ito, Yoshiya; Iwai-Shimada, Miyuki; Yamazaki, Shin; Kamijima, Michihiro; Kishi, Reiko

Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire : A prospective birth cohort

Kobayashi, Sumitaka; Itoh, Sachiko; Miyashita, Chihiro et al.

Environment international, 2022, 168, 107448

Permalink : https://hdl.handle.net/2115/87395

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アクセス権	open access
URI	https://hdl.handle.net/2115/87395
タイトル	Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire : A prospective birth cohort
著者	Kobayashi, Sumitaka ; Itoh, Sachiko ; Miyashita, Chihiro ; Bamai, Yu Ait ; Yamaguchi, Takeshi ; Masuda, Hideyuki ; Itoh, Mariko ; Yamazaki, Keiko ; Tamura, Naomi ; Hanley, Sharon J. B. ; Ikeda-Araki, Atsuko ; Saijo, Yasuaki ; Ito, Yoshiya ; Iwai-Shimada, Miyuki ; Yamazaki, Shin ; Kamijima, Michihiro ; Kishi, Reiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 90752907 著者名 Bamai, Yu Ait
e-Rad_Researcher 80894972 著者名 Yamaguchi, Takeshi
著者名 Masuda, Hideyuki
著者名 Itoh, Mariko
e-Rad_Researcher 60732120 著者名 Yamazaki, Keiko
e-Rad_Researcher 80836164 著者名 Tamura, Naomi
著者名 Hanley, Sharon J. B.
e-Rad_Researcher 00619885 著者名 Ikeda-Araki, Atsuko
著者名 Saijo, Yasuaki
著者名 Ito, Yoshiya
著者名 Iwai-Shimada, Miyuki
著者名 Yamazaki, Shin
著者名 Kamijima, Michihiro
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Mercury
	Selenium
	Pregnancy
	Neurodevelopment
	Ages and Stages Questionnaires
	Japan Environment and Children's Study
発行日	2022-10
出版者	Elsevier
収録物名	Environment international
巻(号)	168
ページ	107448
抄録	Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n(child )= 48,731) and cord (n(child )= 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to < 156 ng/g), the odds ratio (95 % confidence intervals) for problem-solving ability in children of mothers in the third (168 to < 181 ng/g) and fourth quartiles (181 to 976 ng/g) were 1.08 (1.01 to 1.14) and 1.10 (1.04 to 1.17), respectively. Furthermore, communication, gross and fine motor skills, and problem-solving delays were also observed. However, prenatal Hg levels in maternal and cord blood and Se levels in the latter were not associated with neurodevelopmental delays in children. Thus, the findings of this study suggest an association between Se levels in maternal blood and slightly increased risks of neurodevelopmental delays in children up to the age of 4 years.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0160-4120
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.envint.2022.107448