Tumor-Informed Approach Improved ctDNA Detection Rate in Resected Pancreatic Cancer

Watanabe, Kazunori; Nakamura, Toru; Kimura, Yasutoshi; Motoya, Masayo; Kojima, Shigeyuki; Kuraya, Tomotaka; Murakami, Takeshi; Kaneko, Tsukasa; Shinohara, Yoshihito; Kitayama, Yosuke; Fukuda, Keito; Hatanaka, Kanako C.; Mitsuhashi, Tomoko; Pittella-Silva, Fabio; Yamaguchi, Toshikazu; Hirano, Satoshi; Nakamura, Yusuke; Low, Siew-Kee

Tumor-Informed Approach Improved ctDNA Detection Rate in Resected Pancreatic Cancer

Watanabe, Kazunori; Nakamura, Toru; Kimura, Yasutoshi et al.

International Journal of Molecular Sciences, 2022, 23(19), 11521

Permalink : https://hdl.handle.net/2115/87396

このアイテムのアクセス数:368件（2026-08-19 03:29 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.3390/ijms231911521			188

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/87396
タイトル	Tumor-Informed Approach Improved ctDNA Detection Rate in Resected Pancreatic Cancer
著者	Watanabe, Kazunori ; Nakamura, Toru ; Kimura, Yasutoshi ; Motoya, Masayo ; Kojima, Shigeyuki ; Kuraya, Tomotaka ; Murakami, Takeshi ; Kaneko, Tsukasa ; Shinohara, Yoshihito ; Kitayama, Yosuke ; Fukuda, Keito ; Hatanaka, Kanako C. ; Mitsuhashi, Tomoko ; Pittella-Silva, Fabio ; Yamaguchi, Toshikazu ; Hirano, Satoshi ; Nakamura, Yusuke ; Low, Siew-Kee
著者名 Watanabe, Kazunori
e-Rad_Researcher 70645796 著者名 Nakamura, Toru
著者名 Kimura, Yasutoshi
著者名 Motoya, Masayo
著者名 Kojima, Shigeyuki
著者名 Kuraya, Tomotaka
著者名 Murakami, Takeshi
著者名 Kaneko, Tsukasa
著者名 Shinohara, Yoshihito
著者名 Kitayama, Yosuke
著者名 Fukuda, Keito
著者名 Hatanaka, Kanako C.
著者名 Mitsuhashi, Tomoko
著者名 Pittella-Silva, Fabio
著者名 Yamaguchi, Toshikazu
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
著者名 Nakamura, Yusuke
著者名 Low, Siew-Kee
言語	英語
キーワード	cell-free DNA
	circulating tumor DNA
	liquid biopsy
	pancreatic cancer
	tumor-informed approach
	neoadjuvant therapy
	next-generation sequencing
	cancer prognosis
発行日	2022-10
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	23(19)
ページ	11521
抄録	Pancreatic cancer is one of the cancers with very poor prognosis; there is an urgent need to identify novel biomarkers to improve its clinical outcomes. Circulating tumor DNA (ctDNA) from liquid biopsy has arisen as a promising biomarker for cancer detection and surveillance. However, it is known that the ctDNA detection rate in resected pancreatic cancer is low compared with other types of cancer. In this study, we collected paired tumor and plasma samples from 145 pancreatic cancer patients. Plasma samples were collected from 71 patients of treatment-naive status and from 74 patients after neoadjuvant therapy (NAT). Genomic profiling of tumor DNA and plasma samples was conducted using targeted next-generation sequencing (NGS). Somatic mutations were detected in 85% (123/145) of tumors. ctDNA was detected in 39% (28/71) and 31% (23/74) of treatment-naive and after-NAT groups, respectively, without referring to the information of tumor profiles. With a tumor-informed approach (TIA), ctDNA detection rate improved to 56% (40/71) and 36% (27/74) in treatment-naive and after-NAT groups, respectively, with the detection rate significantly improved (p = 0.0165) among the treatment-naive group compared to the after-NAT group. Cases who had detectable plasma ctDNA concordant to the corresponding tumor showed significantly shorter recurrence-free survival (RFS) (p = 0.0010). We demonstrated that TIA improves ctDNA detection rate in pancreatic cancer, and that ctDNA could be a potential prognostic biomarker for recurrence risk prediction
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijms231911521