Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)

Kondo, Mitsuki; Ikenaka, Yoshinori; Nakayama, Shouta M. M.; Kawai, Yusuke K.; Ishizuka, Mayumi

Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)

Kondo, Mitsuki; Ikenaka, Yoshinori; Nakayama, Shouta M. M. et al.

Animals, 2022, 12(21), 2954

Permalink : https://hdl.handle.net/2115/87488

このアイテムのアクセス数:310件（2026-08-13 21:50 集計）

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https://doi.org/10.3390/ani12212954			46

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/87488
タイトル	Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)
著者	Kondo, Mitsuki ; Ikenaka, Yoshinori ; Nakayama, Shouta M. M. ; Kawai, Yusuke K. ; Ishizuka, Mayumi
著者名 Kondo, Mitsuki
著者名 Ikenaka, Yoshinori
著者名 Nakayama, Shouta M. M.
著者名 Kawai, Yusuke K.
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	wildlife
	xenobiotic metabolism
	in silico analysis
	genome database
	phase II metabolism
	glucuronidation
発行日	2022-11
出版者	MDPI
収録物名	Animals
巻(号)	12(21)
ページ	2954
抄録	Simple Summary In this study, we clarified the evolutional features of the UGT gene family in Carnivora. We firstly analyzed the gene synteny of UGT1As, 2Bs, ana 2Es and further demonstrated the phylogenetic analysis to reveal the evolutional gene duplication and loss event in Carnivora. We found specific UGT1A duplication in Canidae, brown bear and black bear, and UGT2Bs duplication in Canidae, some Mustelidae, and Ursidae. In addition, we observed gene contraction of UGT1A7-12 in Phocidae, Otariidae, and Felidae. This study strongly suggested closely related Carnivorans also showed significant evolutional differences of UGTs, and further imply the importance of appropriate approaches to assess pharmacokinetics and toxicokinetic from experimental animals. UDP-glucuronosyltransferases (UGTs) are one of the most important enzymes for xenobiotic metabolism or detoxification. Through duplication and loss of genes, mammals evolved the species-specific variety of UGT isoforms. Among mammals, Carnivora is one of the orders that includes various carnivorous species, yet there is huge variation of food habitat. Recently, lower activity of UGT1A and 2B were shown in Felidae and pinnipeds, suggesting evolutional loss of these isoforms. However, comprehensive analysis for genetic or evolutional features are still missing. This study was conducted to reveal evolutional history of UGTs in Carnivoran species. We found specific gene expansion of UGT1As in Canidae, brown bear and black bear. We also found similar genetic duplication in UGT2Bs in Canidae, and some Mustelidae and Ursidae. In addition, we discovered contraction or complete loss of UGT1A7-12 in phocids, some otariids, felids, and some Mustelids. These studies indicate that even closely related species have completely different evolution of UGTs and further imply the difficulty of extrapolation of the pharmacokinetics and toxicokinetic result of experimental animals into wildlife carnivorans.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2076-2615
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ani12212954