New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents

Haedar, Jabal Rahmat; Uria, Agustinus Robert; Lallo, Subehan; Dibwe, Dya Fita; Wakimoto, Toshiyuki

New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents

Haedar, Jabal Rahmat; Uria, Agustinus Robert; Lallo, Subehan et al.

Marine drugs, 2022, 20(11), 661

Permalink : https://hdl.handle.net/2115/87535

このアイテムのアクセス数:501件（2026-10-16 03:41 集計）

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https://doi.org/10.3390/md20110661			57

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/87535
タイトル	New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents
著者	Haedar, Jabal Rahmat ; Uria, Agustinus Robert ; Lallo, Subehan ; Dibwe, Dya Fita ; Wakimoto, Toshiyuki
著者名 Haedar, Jabal Rahmat
e-Rad_Researcher 40889565 著者名 Uria, Agustinus Robert
著者名 Lallo, Subehan
著者名 Dibwe, Dya Fita
e-Rad_Researcher 70363900 著者名 Wakimoto, Toshiyuki
言語	英語
キーワード	marine sponge
	Theonella swinhoei
	depsipeptide
	preferential cytotoxicity
	theonellapeptolide-type compounds
	anti-pancreatic cancer agents
	anti-austerity agents
発行日	2022-10-25
出版者	MDPI
収録物名	Marine drugs
巻(号)	20(11)
ページ	661
抄録	We reported three new members of the theonellapeptolide family from theonellapeptolide II series, namely theonellapeptolides IIb (1), IIa (2), IIc (3), and three known members-IId (4), IIe (5), and Id (6)-from Kodingarengan marine sponge Theonella swinhoei collected in Makassar, Indonesia. The structures of tridecadepsipeptides 1-3, including the absolute configurations of their amino acids, were determined by the integrated NMR and tandem MS analyses followed by Marfey's analysis. To the best of our knowledge, 1 and 2 are the first theonellapeptolide-type compounds to have a valine residue with (D) configuration at residue position 6. The isolated theonellapeptolide-type compounds 1-6 showed selective cytotoxic activity against human pancreatic MIA PaCa-2 cancer cells in a nutrient-deprived medium. Among them, the most potent preferential cytotoxicity was observed in new theonellapeptolide IIc (3) and known IId (4), IIe (5), and Id (6).
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/md20110661