Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation

Yoshinari, Miku; Nishibata, Yuka; Masuda, Sakiko et al.

Arthritis Research & Therapy, 2022, 24(1), 274

Permalink : https://hdl.handle.net/2115/87589

このアイテムのアクセス数:383件（2026-01-16 23:57 集計）

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https://doi.org/10.1186/s13075-022-02974-9      

論文情報

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アクセス権
metadata only access
URI
https://hdl.handle.net/2115/87589
タイトル
Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation
著者
Yoshinari, Miku ; Nishibata, Yuka ; Masuda, Sakiko ; Nakazawa, Daigo ; Tomaru, Utano ; Arimura, Yoshihiro ; Amano, Koichi ; Yuzawa, Yukio ; Sada, Ken-Ei ; Atsumi, Tatsuya ; Dobashi, Hiroaki ; Hasegawa, Hitoshi ; Harigai, Masayoshi ; Matsuo, Seiichi ; Makino, Hirofumi ; Ishizu, Akihiro
著者名
Yoshinari, Miku
著者名
Nishibata, Yuka
e-Rad_Researcher
10763617
著者名
Masuda, Sakiko
e-Rad_Researcher
60724135
著者名
Nakazawa, Daigo
e-Rad_Researcher
20360901
著者名
Tomaru, Utano
e-Rad_Researcher
40222765
著者名
Arimura, Yoshihiro
e-Rad_Researcher
00175928
著者名
Amano, Koichi
e-Rad_Researcher
00191479
著者名
Yuzawa, Yukio
e-Rad_Researcher
70423308
著者名
Sada, Ken-Ei
e-Rad_Researcher
20301905
著者名
Atsumi, Tatsuya
e-Rad_Researcher
50380176
著者名
Dobashi, Hiroaki
e-Rad_Researcher
40164826
著者名
Hasegawa, Hitoshi
e-Rad_Researcher
20238207
著者名
Harigai, Masayoshi
著者名
Matsuo, Seiichi
e-Rad_Researcher
50165685
著者名
Makino, Hirofumi
e-Rad_Researcher
60321957
著者名
Ishizu, Akihiro
言語
英語
キーワード
MPA
NETs
ANETA
Anti-MYL6 antibody
発行日
2022-12-16
出版者
BioMed Central
収録物名
Arthritis Research & Therapy
巻(号)
24(1)
ページ
274
抄録
Background: Neutrophil extracellular traps (NETs) are critically involved in microscopic polyangiitis (MPA) pathogenesis, and some patients with MPA possess anti-NET antibody (ANETA). Anti-myosin light chain 6 (MYL6) antibody is an ANETA that affects NETs. This study aimed to determine the significance of anti-MYL6 antibody in MPA. Methods: The influence of anti-MYL6 antibody on NET formation and actin rearrangement necessary for NET formation was assessed by fluorescent staining. An enzyme-linked immunosorbent assay was established to detect serum anti-MYL6 antibody, and the prevalence of this antibody in MPA was determined. Furthermore, the disease activity and response to remission-induction therapy of MPA were compared between anti-MYL6 antibody-positive and anti-MYL6 antibody-negative MPA patients. Results: Anti-MYL6 antibody disrupted G-actin polymerization into F-actin, suppressing phorbol 12-myristate 13-acetate-induced NET formation. Serum anti-MYL6 antibody was detected in 7 of 59 patients with MPA. The Birmingham vasculitis activity score (BVAS) of anti-MYL6 antibody-positive MPA patients was significantly lower than anti-MYL6 antibody-negative MPA patients. Among the nine BVAS evaluation items, the cutaneous, cardiovascular, and nervous system scores of anti-MYL6 antibody-positive MPA patients were significantly lower than anti-MYL6 antibody-negative MPA patients, although other items, including the renal and chest scores, were equivalent between the two groups. The proportion of patients with remission 6 months after initiation of remission-induction therapy in anti-MYL6 antibody-positive MPA patients was significantly higher than in anti-MYL6 antibody-negative MPA patients. Conclusions: Collective findings suggested that anti-MYL6 antibody disrupted actin rearrangement necessary for NET formation and could reduce the disease activity of MPA.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1478-6354
EISSN
1478-6362
関連情報
PMID
36527167
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s13075-022-02974-9