STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses

Matsuda, Tadashi; Oritani, Kenji

Biological and Pharmaceutical Bulletin, 2021, 44(7), 895-901

Permalink : https://hdl.handle.net/2115/87607

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/87607
タイトル
STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses
著者
e-Rad_Researcher
20212219
著者名
Matsuda, Tadashi
e-Rad_Researcher
70324762
著者名
Oritani, Kenji
言語
英語
キーワード
signal-transducing adaptor protein (STAP)-2
adaptor protein
immune response
inflammation
signal transduction
発行日
2021-07-01
出版者
The Pharmaceutical Society of Japan
日本薬学会
収録物名
Biological and Pharmaceutical Bulletin
巻(号)
44(7)
ページ
895-901
抄録
Signal-transducing adaptor protein (STAP)-2 is an adaptor molecule involved in regulation of several intracellular signaling events in immune cells. STAP-2 contains a pleckstrin homology domain at the N-terminus, an src homology domain in the central portion and a proline-rich region at the C-terminus. STAP-2 also has a YXXQ motif, which is a potential signal transducer and activator of transcription (STAT)3-binding site. STAP-2 influences the STAT3 and STAT5 activity, integrin-mediated T cell adhesion, chemokine-induced T cell migration, Fas-mediated T cell apoptosis, Toll-like receptor-mediated macrophage functions, macrophage colony-stimulating factor-induced macrophage activation, and the high-affinity immunoglobulin E receptor-mediated mast cell activation. This article reviews the current understanding of roles of the STAP-2 during immune and/or inflammatory responses, and discusses possible therapeutic applications of targeting STAP-2 proteins in immune-related disorders.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0918-6158
EISSN
1347-5215
関連情報
PMID
34193686
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1248/bpb.b21-00224