Possible Therapeutic Applications of Targeting STAP Proteins in Cancer

Matsuda, Tadashi; Oritani, Kenji

Biological & pharmaceutical bulletin, 2021, 44(12), 1810-1818

Permalink : https://hdl.handle.net/2115/87612

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/87612
タイトル
Possible Therapeutic Applications of Targeting STAP Proteins in Cancer
著者
e-Rad_Researcher
20212219
著者名
Matsuda, Tadashi
e-Rad_Researcher
70324762
著者名
Oritani, Kenji
言語
英語
キーワード
signal-transducing adaptor protein (STAP)
adaptor protein
signal transduction
cancer cell growth
tumorigenesis
発行日
2021-12-01
出版者
The Pharmaceutical Society of Japan
日本薬学会
収録物名
Biological & pharmaceutical bulletin
巻(号)
44(12)
ページ
1810-1818
抄録
The signal-transducing adaptor protein (STAP) family, including STAP-1 and STAP-2, contributes to a variety of intracellular signaling pathways. The proteins in this family contain typical structures for adaptor proteins, such as Pleckstrin homology in the N-terminal regions and SRC homology 2 domains in the central regions. STAP proteins bind to inhibitor of kappaB kinase complex, breast tumor kinase, signal transducer and activator of transcription 3 (STAT3), and STAT5, during tumorigenesis and inflammatory/immune responses. STAP proteins positively or negatively regulate critical steps in intracellular signaling pathways through individually unique mechanisms. This article reviews the roles of the novel STAP family and the possible therapeutic applications of targeting STAP proteins in cancer.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0918-6158
EISSN
1347-5215
関連情報
PMID
34853263
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1248/bpb.b21-00672