Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan

Kobayashi, Sumitaka; Sata, Fumihiro; Ikeda-Araki, Atsuko; Miyashita, Chihiro; Minatoya, Machiko; Ikeno, Tamiko; Kato, Shizue; Fujikura, Kaori; Mizutani, Futoshi; Chisaki, Yoichi; Kishi, Reiko

Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan

Kobayashi, Sumitaka; Sata, Fumihiro; Ikeda-Araki, Atsuko et al.

Reproductive Toxicology, 2022, 107, 112-122

Permalink : https://hdl.handle.net/2115/87636

このアイテムのアクセス数:447件（2026-01-18 23:33 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/87636
タイトル	Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan
著者	Kobayashi, Sumitaka ; Sata, Fumihiro ; Ikeda-Araki, Atsuko ; Miyashita, Chihiro ; Minatoya, Machiko ; Ikeno, Tamiko ; Kato, Shizue ; Fujikura, Kaori ; Mizutani, Futoshi ; Chisaki, Yoichi ; Kishi, Reiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Sata, Fumihiro
e-Rad_Researcher 00619885 著者名 Ikeda-Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
著者名 Kato, Shizue
著者名 Fujikura, Kaori
著者名 Mizutani, Futoshi
著者名 Chisaki, Yoichi
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Perfluoroalkyl substance
	Pregnancy
	Polymorphism
	Liver X receptor
	Birth size
	Ponderal index
発行日	2022-01
出版者	Elsevier
収録物名	Reproductive Toxicology
巻(号)	107
ページ	112-122
抄録	We assessed the associations between perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) levels in third trimester maternal serum, the maternal genotypes of genes encoding nuclear receptors, and birth outcomes. We studied a prospective birth cohort of healthy pregnant Japanese women (n = 372) recruited in Sapporo between July 2002 and October 2005. We analyzed PFOS and PFOA levels using liquid chromatography-tandem mass spectrometry and analyzed 13 single nucleotide polymorphisms (SNPs) of proliferator-activated receptor alpha, gamma, gamma coactivator 1A, delta, constitutive androstane receptor, liver X receptor alpha, and beta (LXRB) using real-time polymerase reaction (PCR). We employed multiple linear regression models to establish the influences of log10-transformed PFOS and PFOA levels and maternal genotypes on birth size. In female infants, we identified interactions between PFOS levels, the maternal genotype of LXRB (rs1405655), and birth weight. The estimated mean changes in birth weight in response to PFOS levels, the maternal genotype LXRB (rs1405655)-TC/CC (compared to TT), and their interactions were -502.9 g (95 % confidence interval [CI] = -247.3, -758.5 g), -526.3 g (95 % CI = -200.7, -852.0 g), and 662.1 g (95 % CI = 221.0, 1,103.2 g; pint = 0.003), respectively. Interactions between PFOS levels and the maternal genotype of LXRB (rs1405655) also significantly affected birth chest circumference and the Ponderal index (pint = 0.037 and 0.005, respectively). Thus, interactions between PFOS levels and the maternal genotype of LXRB (rs1405655) affects birth sizes in female infants. We found that certain SNPs modify the effects of PFOS levels on birth size.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0890-6238
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.reprotox.2021.12.004