Autophagy during left ventricular redilation after ventrictuoulasty : Insights from a rat model of ischemic cardiomyopathy

Sugimoto, Satoshi; Shingu, Yasushige; Doenst, Torsten; Yamakawa, Tomoji; Asai, Hidetsugu; Wakasa, Satoru; Matsui, Yoshiro

Autophagy during left ventricular redilation after ventrictuoulasty : Insights from a rat model of ischemic cardiomyopathy

Sugimoto, Satoshi; Shingu, Yasushige; Doenst, Torsten et al.

Journal of Thoracic and Cardiovascular Surgery, 2022, 163(1), e33-e40

Permalink : https://hdl.handle.net/2115/87637

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アクセス権	open access
URI	https://hdl.handle.net/2115/87637
タイトル	Autophagy during left ventricular redilation after ventrictuoulasty : Insights from a rat model of ischemic cardiomyopathy
著者	Sugimoto, Satoshi ; Shingu, Yasushige ; Doenst, Torsten ; Yamakawa, Tomoji ; Asai, Hidetsugu ; Wakasa, Satoru ; Matsui, Yoshiro
著者名 Sugimoto, Satoshi
e-Rad_Researcher 30617064 著者名 Shingu, Yasushige
著者名 Doenst, Torsten
著者名 Yamakawa, Tomoji
著者名 Asai, Hidetsugu
e-Rad_Researcher 10374365 著者名 Wakasa, Satoru
e-Rad_Researcher 90219379 著者名 Matsui, Yoshiro
言語	英語
キーワード	ischemic cardiomyopathy
	left ventriculoplasty
	autophagy
	left ventricular redilation
	myocardial hypertrophy
発行日	2022-01-01
出版者	Elsevier
収録物名	Journal of Thoracic and Cardiovascular Surgery
巻(号)	163(1)
ページ	e33-e40
抄録	Objectives: Myocardial autophagy has been recognized as an important factor in heart failure. It is not known whether changes in ventricular geometry by left ventriculoplasty influence autophagy in ischemic cardiomyopathy. We hypothesized that myocardial autophagy plays an important role in left ventricular (LV) redilation after ventriculoplasty. Methods: Four weeks after ligation of the left anterior descending artery, ventriculoplasty or sham operation was performed. The animals were euthanized at 2 days (early) or 28 days (late) after the second operation. Ventricular autophagy was evaluated by protein expression of microtubule-associated protein light chain 3 II, an autophagosome marker. Cardiomyocyte area was assessed by histologic examination. LV function was evaluated by echocardiography. To examine the implications of autophagy, an autophagy inhibitor (3-methyladenine) was injected intraperitoneally for 3 weeks before sacrifice. Results: The LV was reduced in size early and redilated late after ventriculoplasty. LV systolic function was improved early and later worsened after ventriculoplasty. Light chain 3 II expression decreased early after ventriculoplasty and increased in the late period. Myocyte area increased from the early to late stage after ventriculoplasty. Autophagic inhibition exaggerated the increased myocyte hypertrophy and LV redilation. Conclusions: In a rat model of myocardial infarction, autophagy decreased early after ventriculoplasty and increased again during LV redilation. These results provide new insights into the mechanism underlying the late failure of ventriculoplasty.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0022-5223
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jtcvs.2020.01.080