Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery

Sasaki, Akihiro; Kato, Tatsuya; Ujiie, Hideki; Wakasa, Satoru; Otake, Setsuyuki; Kikuchi, Keisuke; Ohno, Koichi

Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery

Sasaki, Akihiro; Kato, Tatsuya; Ujiie, Hideki et al.

Annals of Thoracic and Cardiovascular Surgery, 2022, 28(6), 448-452

Permalink : https://hdl.handle.net/2115/87640

このアイテムのアクセス数:291件（2026-08-24 07:53 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/87640
タイトル	Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery
著者	Sasaki, Akihiro ; Kato, Tatsuya ; Ujiie, Hideki ; Wakasa, Satoru ; Otake, Setsuyuki ; Kikuchi, Keisuke ; Ohno, Koichi
著者名 Sasaki, Akihiro
著者名 Kato, Tatsuya
著者名 Ujiie, Hideki
著者名 Wakasa, Satoru
著者名 Otake, Setsuyuki
著者名 Kikuchi, Keisuke
著者名 Ohno, Koichi
言語	英語
キーワード	stiff-person syndrome
	paraneoplastic stiff-person syndrome
	thymoma
	anti-acetylcholine receptor antibody
	myasthenia gravis
発行日	2022-12
出版者	The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
収録物名	Annals of Thoracic and Cardiovascular Surgery
巻(号)	28(6)
ページ	448-452
抄録	Introduction: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder.Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately5% of all SPS cases. We present a rare case of thymoma accompanied by SPSsuccessfully treated using surgery.Presentation of Case: A 26-year-old woman presented with lower limbs convulsions andgait disturbance and complained of leg pain. Cerebrospinal fluid and blood test resultsshowed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computedtomography showed anterior mediastinal tumor suggestive of a thymoma. She underwentextended thymectomy, and her symptoms gradually improved after surgery. No evidenceof recurrent thymoma and SPS has been observed over 44 months.Conclusion: Surgical treatment would be effective for patients with SPS and thymoma.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1341-1098
EISSN	2186-1005
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.5761/atcs.cr.21-00052