Signal-transducing adaptor protein-2 modulates T-cell functions

Matsuda, Tadashi; Sasaki, Yuto; Kagohashi, Kota; Saitoh, Kodai; Sekine, Yuichi; Kashiwakura, Jun-Ichi; Oritani, Kenji

Signal-transducing adaptor protein-2 modulates T-cell functions

Matsuda, Tadashi; Sasaki, Yuto; Kagohashi, Kota et al.

Exploration of Immunology, 2022, 2022(2), 771-782

Permalink : https://hdl.handle.net/2115/87690

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アクセス権	open access
URI	https://hdl.handle.net/2115/87690
タイトル	Signal-transducing adaptor protein-2 modulates T-cell functions
著者	Matsuda, Tadashi ; Sasaki, Yuto ; Kagohashi, Kota ; Saitoh, Kodai ; Sekine, Yuichi ; Kashiwakura, Jun-Ichi ; Oritani, Kenji
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
著者名 Sasaki, Yuto
著者名 Kagohashi, Kota
著者名 Saitoh, Kodai
e-Rad_Researcher 20396295 著者名 Sekine, Yuichi
e-Rad_Researcher 90373290 著者名 Kashiwakura, Jun-Ichi
e-Rad_Researcher 70324762 著者名 Oritani, Kenji
言語	英語
キーワード	Signal-transducing adaptor protein
	adaptor protein
	signal transduction
	T-cell
	immune response
	autoimmunity
	chimeric antigen receptor T-cells
発行日	2022-12-27
出版者	Open Exploration
収録物名	Exploration of Immunology
巻(号)	2022(2)
ページ	771-782
抄録	Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades. Signal-transducing adaptor protein-2 (STAP-2) contains typical features of adaptor proteins, like a pleckstrin homology (PH) domain in the N-terminal region and a Src homology 2 (SH2) domain in the central region. STAP-2 binds to a variety of signaling or transcriptional molecules to control multiple steps of inflammatory/immune responses. STAP-2 enhances T-cell receptor (TCR)-mediated signaling via the association with TCR-proximal CD3ζ immunoreceptor tyrosine-based activation motifs (ITAMs) and lymphocyte-specific protein tyrosine kinase (Lck). STAP-2 decreases adherence of T-cells to fibronectin (FN) through an association with focal adhesion kinase (Fak) and Casitas B-lineage Lymphoma (c-Cbl), and increases chemotaxis of T-cells toward stromal cell-derived factor-1α (SDF-1α) through interactions with Vav1 and Ras-related C3 botulinum toxin substrate 1 (Rac1). STAP-2 positively regulates activation-induced cell deathrough the association with Fas and caspase-8. This review describes the current knowledge of the roles of STAP-2 in T-cell-dependent immune responses and the possible clinical utility of STAP-2-targeting therapies.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	2768-6655
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.37349/ei.2022.00082