A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling

Maemoto, Taiga; Kitai, Yuichi; Takahashi, Runa; Shoji, Haruka; Yamada, Shunsuke; Takei, Shiho; Ito, Daiki; Muromoto, Ryuta; Kashiwakura, Jun-ichi; Handa, Haruka; Hashimoto, Ari; Hashimoto, Shigeru; Ose, Toyoyuki; Oritani, Kenji; Matsuda, Tadashi

A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling

Maemoto, Taiga; Kitai, Yuichi; Takahashi, Runa et al.

Journal of Biological Chemistry, 2022, 299(1), 102724

Permalink : https://hdl.handle.net/2115/87706

このアイテムのアクセス数:435件（2026-01-14 07:49 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/87706
タイトル	A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling
著者	Maemoto, Taiga ; Kitai, Yuichi ; Takahashi, Runa ; Shoji, Haruka ; Yamada, Shunsuke ; Takei, Shiho ; Ito, Daiki ; Muromoto, Ryuta ; Kashiwakura, Jun-ichi ; Handa, Haruka ; Hashimoto, Ari ; Hashimoto, Shigeru ; Ose, Toyoyuki ; Oritani, Kenji ; Matsuda, Tadashi
著者名 Maemoto, Taiga
e-Rad_Researcher 90756165 著者名 Kitai, Yuichi
著者名 Takahashi, Runa
著者名 Shoji, Haruka
著者名 Yamada, Shunsuke
著者名 Takei, Shiho
著者名 Ito, Daiki
e-Rad_Researcher 30455597 著者名 Muromoto, Ryuta
e-Rad_Researcher 90373290 著者名 Kashiwakura, Jun-ichi
著者名 Handa, Haruka
e-Rad_Researcher 60390803 著者名 Hashimoto, Ari
e-Rad_Researcher 50311303 著者名 Hashimoto, Shigeru
e-Rad_Researcher 80380525 著者名 Ose, Toyoyuki
e-Rad_Researcher 70324762 著者名 Oritani, Kenji
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	antitumor peptide
	prostate cancer
	STAT3
	EGFR
	adaptor protein
発行日	2022-11-19
出版者	American Society for Biochemistry and Molecular Biology
収録物名	Journal of Biological Chemistry
巻(号)	299(1)
ページ	102724
抄録	Signal-transducing adaptor family member-2 (STAP-2) is an adaptor protein that regulates various intracellular signals. We previously demonstrated that STAP-2 binds to epidermal growth factor receptor (EGFR) and facilitates its stability and activation of EGFR signaling in prostate cancer cells. Inhibition of this interaction may be a promising direction for cancer treatment. Here, we found that 2D5 peptide, a STAP-2–derived peptide, blocked STAP-2–EGFR interactions and suppressed EGFR-mediated proliferation in several cancer cell lines. 2D5 peptide inhibited tumor growth of human prostate cancer cell line DU145 and human lung cancer cell line A549 in murine xenograft models. Additionally, we determined that EGFR signaling and its stability were decreased by 2D5 peptide treatment during EGF stimulation. In conclusion, our study shows that 2D5 peptide is a novel anticancer peptide that inhibits STAP-2–mediated activation of EGFR signaling and suppresses prostate and lung cancer progression.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	0021-9258
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.jbc.2022.102724