open access

https://hdl.handle.net/2115/87712

Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal-induced aversive behavior

英語

noradrenaline

2022-04-19

John Wiley & Sons

Neuropsychopharmacology Reports

42(2)

233-237

Aim: Cessation of smoking induces nicotine withdrawal symptoms such as anxiety, depression, and dysphoria, which could lead to smoking relapse. In the present study, we examined the role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis (vBNST) on nicotine withdrawal-induced aversive behavior. Methods: Nicotine dependence in rats was established by subcutaneous implantation with a nicotine-filled osmotic minipump on day 1. Nicotine withdrawal was precipi-tated by administration of the nicotine receptor antagonist, mecamylamine (3.0 mg/kg, s.c.), on day 15. Nicotine withdrawal-induced intra-vBNST noradrenaline release and aversive behavior were examined by in vivo microdialysis and a conditioned place aversion (CPA) test, respectively. Results: Intra-vBNST noradrenaline release was significantly increased during nico-tine withdrawal. Nicotine withdrawal induced aversive behavior, which was attenu-ated by intra-vBNST injection of the β- adrenoceptor antagonist, timolol. Conclusions: These results suggest that enhanced noradrenergic transmission via β- adrenoceptors in the vBNST plays a crucial role in nicotine withdrawal-induced aver-sive behavior.

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