Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia

Nakata, Hokuto; Nakayama, Shouta M. M.; Yabe, John; Muzandu, Kaampwe; Toyomaki, Haruya; Yohannes, Yared Beyene; Kataba, Andrew; Zyambo, Golden; Ikenaka, Yoshinori; Choongo, Kennedy; Ishizuka, Mayumi

Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia

Nakata, Hokuto; Nakayama, Shouta M. M.; Yabe, John et al.

Chemosphere, 2021, 262, 127788

Permalink : https://hdl.handle.net/2115/87839

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/87839
タイトル	Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia
著者	Nakata, Hokuto ; Nakayama, Shouta M. M. ; Yabe, John ; Muzandu, Kaampwe ; Toyomaki, Haruya ; Yohannes, Yared Beyene ; Kataba, Andrew ; Zyambo, Golden ; Ikenaka, Yoshinori ; Choongo, Kennedy ; Ishizuka, Mayumi
著者名 Nakata, Hokuto
著者名 Nakayama, Shouta M. M.
著者名 Yabe, John
著者名 Muzandu, Kaampwe
著者名 Toyomaki, Haruya
著者名 Yohannes, Yared Beyene
著者名 Kataba, Andrew
著者名 Zyambo, Golden
著者名 Ikenaka, Yoshinori
著者名 Choongo, Kennedy
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Liver function
	Kidney function
	ALAD activity
	Lead
	Cadmium
	Mining site
発行日	2021-01
出版者	Elsevier
収録物名	Chemosphere
巻(号)	262
ページ	127788
抄録	Lead (Pb) interferes with various bodily functions. Although high blood Pb (Pb-B) levels in residents from Kabwe, Zambia have been reported, the accumulation pattern of other metals remains unknown. The study was designed to determine the Pb-B, blood cadmium (Cd-B), and zinc (Zn-B) values of 504 representative samples from Kabwe, as well as the potential associated adverse health effects. The Pb-B level ranged from 0.79 to 154.75 mu g/dL and generally increased in areas near the mine. A significant elevation of Cd-B was observed in two areas (0.37 +/- 0.26 and 0.32 +/- 0.30 mu g/L) where the two highest mean Pb-B levels were recorded. By contrast, the Zn-B values did not differ greatly with respect to area. Some blood biochemical parameters relating to hepatic and renal functions were out of the normal range in approximately 20-50% of studied adult participants. The delta-aminolevulinic acid dehydratase (delta -ALAD) activity was significantly inhibited in the two areas contaminated by Pb and Cd. A significant negative relationship was observed between metal levels and clinical parameters, e.g., between Pb-B and delta -ALAD for all the age categories and between Cd-B and the estimated glomerular filtration rate for all the age categories except 0-4 years. The elevated Cd-B in areas near the mine relative to the other areas suggested the potential adverse health effects of Cd and/or the interaction of Pb and Cd. A significant association of metal levels with clinical parameters also indicated the effects of metal exposure on hematopoietic, hepatic, and renal systems. (C) 2020 Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0045-6535
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.chemosphere.2020.127788