Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population : The DOSANCO Health Study

Nakamura, Koshi; Hui, Shu-Ping; Ukawa, Shigekazu; Okada, Emiko; Nakagawa, Takafumi; Imae, Akihiro; Okabe, Hiroaki; Chen, Zhen; Miura, Yusuke; Chiba, Hitoshi; Tamakoshi, Akiko

Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population : The DOSANCO Health Study

Nakamura, Koshi; Hui, Shu-Ping; Ukawa, Shigekazu et al.

Journal of epidemiology, 2023, 33(1), 31-37

Permalink : https://hdl.handle.net/2115/87851

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https://doi.org/10.2188/jea.JE20210007			3

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/87851
タイトル	Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population : The DOSANCO Health Study
著者	Nakamura, Koshi ; Hui, Shu-Ping ; Ukawa, Shigekazu ; Okada, Emiko ; Nakagawa, Takafumi ; Imae, Akihiro ; Okabe, Hiroaki ; Chen, Zhen ; Miura, Yusuke ; Chiba, Hitoshi ; Tamakoshi, Akiko
著者名 Nakamura, Koshi
著者名 Hui, Shu-Ping
著者名 Ukawa, Shigekazu
著者名 Okada, Emiko
著者名 Nakagawa, Takafumi
著者名 Imae, Akihiro
著者名 Okabe, Hiroaki
著者名 Chen, Zhen
著者名 Miura, Yusuke
著者名 Chiba, Hitoshi
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
言語	英語
キーワード	25-hydroxyvitamin D3
	diabetes
	insulin resistance
	Japanese
発行日	2023-01
出版者	日本疫学会(Japan Epidemiological Association)JEA
収録物名	Journal of epidemiology
巻(号)	33(1)
ページ	31-37
抄録	Background: Both decreased insulin sensitivity and impaired insulin secretion are common in Asian populations with diabetes, in contrast to Western populations. There is limited evidence regarding the association between insulin response in diabetes in Asian populations and serum 25-hydroxyvitamin D3 (25[OH]D3) insufficiency.Methods: The present cross-sectional study compared the prevalence of diabetes, defined as a fasting plasma glucose level >= 126 mg/dL and/or a HbA1c level >= 6.5%, among 480 participants aged 35-79 years not taking anti-diabetes medications, based on serum 25(OH)D3 levels. A logistic regression model was used to calculate the odds ratios for diabetes in each serum 25(OH)D3 group. Furthermore, this study examined the association between serum 25(OH)D3 levels and the index of homeostasis model assessment of insulin resistance (HOMA-IR) using a linear regression model.Results: The prevalence of diabetes was 7.29% in the study population, and was higher in lower serum 25(OH)D3 quartile groups. The odds ratios for diabetes in the first, second, and third serum 25(OH)D3 quartile groups (25[OH]D3: <= 18.10, 18.11-22.90, and 22.91-28.17 ng/mL) were 4.02 (95% confidence interval [CI], 1.25-12.92), 2.50 (95% CI, 0.77-8.10), and 1.91 (95% CI, 0.60-6.09), respectively, with the fourth quartile group (> 28.18 ng/mL) serving as the reference group, after adjusting for sociodemographic, lifestyle, physical and environmental factors. Serum 25(OH)D3 levels showed an inverse association with log-transformed HOMA-IR after adjusting for similar factors (standardized beta = -0.08; 95% CI, -0.14 to -0.02).Conclusion: Serum 25(OH)D3 levels were inversely associated with diabetes prevalence in a general Japanese population, with a slight inverse association between serum 25(OH)D3 levels and HOMA-IR.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0917-5040
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2188/jea.JE20210007