Association of longitudinal changes in quality of life with comorbidities and exacerbations in patients with severe asthma

Matsumoto-Sasaki, Machiko; Suzuki, Masaru; Kimura, Hirokazu; Shimizu, Kaoruko; Makita, Hironi; Nishimura, Masaharu; Konno, Satoshi

Association of longitudinal changes in quality of life with comorbidities and exacerbations in patients with severe asthma

Matsumoto-Sasaki, Machiko; Suzuki, Masaru; Kimura, Hirokazu et al.

Allergology international, 2022, 71(4), 481-489

Permalink : https://hdl.handle.net/2115/88010

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https://doi.org/10.1016/j.alit.2022.05.009

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/88010
タイトル	Association of longitudinal changes in quality of life with comorbidities and exacerbations in patients with severe asthma
著者	Matsumoto-Sasaki, Machiko ; Suzuki, Masaru ; Kimura, Hirokazu ; Shimizu, Kaoruko ; Makita, Hironi ; Nishimura, Masaharu ; Konno, Satoshi
著者名 Matsumoto-Sasaki, Machiko
e-Rad_Researcher 10374290 著者名 Suzuki, Masaru
著者名 Kimura, Hirokazu
著者名 Shimizu, Kaoruko
著者名 Makita, Hironi
著者名 Nishimura, Masaharu
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
言語	英語
キーワード	Comorbidities
	Exacerbation
	Longitudinal assessment
	Quality of life
	Severe asthma
発行日	2022-10
出版者	Japanese Society Allergology
収録物名	Allergology international
巻(号)	71(4)
ページ	481-489
抄録	Background: Quality of life (QoL) assessment is important in the management of severe asthma, and comorbidities and/or exacerbations may affect longitudinal QoL. However, there are few reports on the longitudinal assessment of QoL in patients with asthma over multiple years and its related factors. This study aimed to clarify the relationship of longitudinal changes in QoL with comorbidities and/or exacerbations during a prolonged observation period in patients with severe asthma. Methods: A total of 105 subjects who participated in the Hokkaido-based Investigative Cohort Analysis for Refractory Asthma (Hi-CARAT) with a six-year follow-up were analyzed. QoL was assessed annually, using the Standardized Asthma Quality of Life Questionnaire, and the subjects were divided into three groups: (1) persistently good QoL, (2) persistently poor QoL, and (3) fluctuating QoL. Assessed comorbidities comprised depression, gastroesophageal reflux disease, and excessive daytime sleepiness (EDS), a key symptom of obstructive sleep apnea. Results: Of 105 subjects with severe asthma, 53 (50%) were classified in the persistently good QoL group, 10 (10%) in the persistently poor QoL group, and 42 (40%) in the fluctuating QoL group. The persistently poor QoL group was associated with shorter time to hospitalization due to exacerbation and the presence of multiple comorbidities. In addition, the presence of EDS was an independent contributor to the fluctuating QoL group compared to the persistently good QoL group. Conclusions: The presence of multiple comorbidities and hospitalization due to exacerbation contribute to longitudinal changes in QoL in patients with severe asthma. Copyright (c) 2022, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1323-8930
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.alit.2022.05.009