Salvage surgery improves the treatment outcome of patients with residual/recurrent maxillary sinus cancer after superselective intra-arterial cisplatin infusion with concomitant radiation therapy

Tsushima, Nayuta; Kano, Satoshi; Suzuki, Takayoshi; Idogawa, Hiroshi; Yoshida, Daisuke; Yasuda, Koichi; Otsuka, Manami; Aoyama, Hidefumi; Homma, Akihiro

Salvage surgery improves the treatment outcome of patients with residual/recurrent maxillary sinus cancer after superselective intra-arterial cisplatin infusion with concomitant radiation therapy

Tsushima, Nayuta; Kano, Satoshi; Suzuki, Takayoshi et al.

European Archives of Oto-Rhino-Laryngology, 2022, 279(2), 899-905

Permalink : https://hdl.handle.net/2115/88120

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アクセス権	open access
URI	https://hdl.handle.net/2115/88120
タイトル	Salvage surgery improves the treatment outcome of patients with residual/recurrent maxillary sinus cancer after superselective intra-arterial cisplatin infusion with concomitant radiation therapy
著者	Tsushima, Nayuta ; Kano, Satoshi ; Suzuki, Takayoshi ; Idogawa, Hiroshi ; Yoshida, Daisuke ; Yasuda, Koichi ; Otsuka, Manami ; Aoyama, Hidefumi ; Homma, Akihiro
e-Rad_Researcher 50547643 著者名 Tsushima, Nayuta
著者名 Kano, Satoshi
著者名 Suzuki, Takayoshi
著者名 Idogawa, Hiroshi
著者名 Yoshida, Daisuke
著者名 Yasuda, Koichi
著者名 Otsuka, Manami
著者名 Aoyama, Hidefumi
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
言語	英語
キーワード	Maxillary sinus cancer
	Salvage surgery
	Intra-arterial
	Chemotherapy
	Radio therapy
	Unresectable
発行日	2022-02-01
出版者	Springer
収録物名	European Archives of Oto-Rhino-Laryngology
巻(号)	279(2)
ページ	899-905
抄録	Purpose We have performed superselective intra-arterial cisplatin infusion with concomitant radiotherapy (RADPLAT) for patients with maxillary sinus cancer. The promising treatment outcomes of this non-surgical treatment were reported in past studies. However, few clinical studies have been conducted to evaluate the outcome of salvage surgery following RADPLAT. The purpose of this study was to analyze the treatment outcomes of salvage surgery for patients with recurrent maxillary sinus cancer after RADPLAT. Methods We assessed 45 patients who had recurrence following RADPLAT between 1999 and 2017, and conducted a retrospective analysis. We excluded patients who did not complete RADPLAT. Patients were not considered to have completed RADPLAT if they underwent intra-arterial cisplatin less than three times or received a total radiation dose of less than 60 Gy. The primary endpoint was overall survival. The median follow-up period for surviving patients after recurrence was 5.1 years. Results Twenty-five of the 45 (56%) patients underwent salvage surgery. The 5-year overall survival rate was 68% in patients who underwent salvage surgery, while all patients who did not undergo salvage surgery died during the observation period. Fifteen of 24 (63%) patients with local recurrence underwent salvage surgery. Eight patients did not undergo salvage surgery because of unresectable disease; five of the eight patients had unresectable posterior extension. All nine patients with nodal recurrence underwent neck dissection. Conclusion Treatment outcomes of salvage surgery following RADPLAT were favorable enough for it to be generally recommended. To reduce unresectable recurrence, the posterior section should be eradicated by RADPLAT.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in European Archives of Oto-Rhino-Laryngology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00405-021-06822-5
PISSN	0937-4477
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00405-021-06822-5