Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy

Hieda, Tetsuya; Shingu, Yasushige; Sugimoto, Satoshi; Asai, Hidetsugu; Yamakawa, Tomoji; Wakasa, Satoru

Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy

Hieda, Tetsuya; Shingu, Yasushige; Sugimoto, Satoshi et al.

Heart and vessels, 2022, 37(3), 528-537

Permalink : https://hdl.handle.net/2115/88191

このアイテムのアクセス数:400件（2026-03-04 23:15 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/88191
タイトル	Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy
著者	Hieda, Tetsuya ; Shingu, Yasushige ; Sugimoto, Satoshi ; Asai, Hidetsugu ; Yamakawa, Tomoji ; Wakasa, Satoru
著者名 Hieda, Tetsuya
e-Rad_Researcher 30617064 著者名 Shingu, Yasushige
著者名 Sugimoto, Satoshi
著者名 Asai, Hidetsugu
著者名 Yamakawa, Tomoji
e-Rad_Researcher 10374365 著者名 Wakasa, Satoru
言語	英語
キーワード	Autophagy
	Ischemic cardiomyopathy
	Surgical ventricular reconstruction
	Trehalose
発行日	2022-03-01
出版者	Springer
収録物名	Heart and vessels
巻(号)	37(3)
ページ	528-537
抄録	Recurrence of left ventricular (LV) remodeling after surgical ventricular reconstruction (SVR) for ischemic cardiomyopathy has been reported to be partially attributed to autophagy. We aimed to examine the effects of trehalose, an autophagy inducer, on the recurrence of LV remodeling after SVR. After SVR in rats with ICM, trehalose was orally administered. The changes in LV end-diastolic dimension (LVEDD) and fractional shortening (FS) were evaluated. The activation of myocardial autophagy was also estimated by autophagy markers: microtubule-associated light chain 3 II (LC3-II) and p62; the former usually increases and the latter decreases if autophagy is activated. Significant LV reverse remodeling was observed early after SVR. On the other hand, the 28th postoperative day SVR + trehalose was associated with smaller LVEDD and better FS than SVR alone (LVEDD, P = 0.043; FS, P < 0.01). LC3-II increased comparably in both groups, while p62 was significantly lower in the SVR + trehalose group than in the SVR alone group (P < 0.01). In conclusion, trehalose attenuated the recurrence of LV remodeling and changed autophagy markers after SVR in rats with ICM. Trehalose may be a candidate for adjuvant therapy to retain the effects of SVR.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00380-021-01990-0
PISSN	0910-8327
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00380-021-01990-0