Mammaglobin 1 mediates progression of trastuzumab-resistant breast cancer cells through regulation of cyclins and NF-κB

Kusumastuti, Ratih; Kumagai, Yuji; Ishihara, Seiichiro; Enomoto, Atsushi; Murakami, Takashi; Yasuda, Motoaki; Haga, Hisashi

Mammaglobin 1 mediates progression of trastuzumab-resistant breast cancer cells through regulation of cyclins and NF-κB

Kusumastuti, Ratih; Kumagai, Yuji; Ishihara, Seiichiro et al.

Febs open bio, 2022, 12(10), 1797-1813

Permalink : https://hdl.handle.net/2115/88243

このアイテムのアクセス数:299件（2026-10-12 12:19 集計）

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https://doi.org/10.1002/2211-5463.13468			41

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/88243
タイトル	Mammaglobin 1 mediates progression of trastuzumab-resistant breast cancer cells through regulation of cyclins and NF-κB
著者	Kusumastuti, Ratih ; Kumagai, Yuji ; Ishihara, Seiichiro ; Enomoto, Atsushi ; Murakami, Takashi ; Yasuda, Motoaki ; Haga, Hisashi
著者名 Kusumastuti, Ratih
著者名 Kumagai, Yuji
e-Rad_Researcher 10719933 著者名 Ishihara, Seiichiro
e-Rad_Researcher 20432255 著者名 Enomoto, Atsushi
e-Rad_Researcher 00326852 著者名 Murakami, Takashi
e-Rad_Researcher 90239765 著者名 Yasuda, Motoaki
e-Rad_Researcher 00292045 著者名 Haga, Hisashi
言語	英語
キーワード	cyclin
	invasion
	MGB1
	migration
	resistance
	trastuzumab
発行日	2022-07-29
出版者	John Wiley & Sons
収録物名	Febs open bio
巻(号)	12(10)
ページ	1797-1813
抄録	Overexpression of human epidermal growth factor receptor 2 (HER2) in various cancers is correlated with poor patient survival. Trastuzumab, a recombinant humanized monoclonal antibody against HER2, has been considered to be a first-line therapy for HER2-positive breast cancer patients, but its usefulness is limited by the development of resistance. In this study, we established resistant cells by long-term treatment with trastuzumab. These cells showed higher proliferation, invasion, and migration abilities than the wild-type cells. Mammaglobin 1 (MGB1), cyclin D1, E1, A2, and phosphorylated NF-κB (p-p65) were upregulated in resistant cells. These proteins regulate cell proliferation, migration, and invasion of resistant cells. Depletion of MGB1 decreased cyclin and p-p65 expression. Cyclin D1 and A2, but not E1 expression, were affected by p-p65 downregulation. In summary, our results indicate that MGB1 expression is increased in breast cancer cells that have gained resistance to trastuzumab, and suggest that MGB1 promotes aggressiveness through cyclin and NF-κB regulation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2211-5463
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/2211-5463.13468