Association between an Increased Serum CCL5 Level and Pathophysiology of Degenerative Joint Disease in the Temporomandibular Joint in Females

Watanabe, Haruhisa; Iori, Takashi; Lee, Ji-Won; Kajii, Takashi S. S.; Takakura, Aya; Takao-Kawabata, Ryoko; Kitagawa, Yoshimasa; Maruoka, Yutaka; Iimura, Tadahiro

Association between an Increased Serum CCL5 Level and Pathophysiology of Degenerative Joint Disease in the Temporomandibular Joint in Females

Watanabe, Haruhisa; Iori, Takashi; Lee, Ji-Won et al.

International Journal of Molecular Sciences, 2023, 24(3), 2775

Permalink : https://hdl.handle.net/2115/88548

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https://doi.org/10.3390/ijms24032775

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/88548
タイトル	Association between an Increased Serum CCL5 Level and Pathophysiology of Degenerative Joint Disease in the Temporomandibular Joint in Females
著者	Watanabe, Haruhisa ; Iori, Takashi ; Lee, Ji-Won ; Kajii, Takashi S. S. ; Takakura, Aya ; Takao-Kawabata, Ryoko ; Kitagawa, Yoshimasa ; Maruoka, Yutaka ; Iimura, Tadahiro
著者名 Watanabe, Haruhisa
著者名 Iori, Takashi
e-Rad_Researcher 70711274 著者名 Lee, Ji-Won
著者名 Kajii, Takashi S. S.
著者名 Takakura, Aya
著者名 Takao-Kawabata, Ryoko
e-Rad_Researcher 00224957 著者名 Kitagawa, Yoshimasa
e-Rad_Researcher 10323726 著者名 Maruoka, Yutaka
e-Rad_Researcher 20282775 著者名 Iimura, Tadahiro
キーワード	CCL5
	temporomandibular joint
	degenerative joint disease
	mandible
	joint
	bone metabolism
	osteoarthritis
発行日	2023-02-01
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	24(3)
ページ	2775
抄録	Degenerative joint disease of the temporomandibular joints (DJD-TMJ) clinically manifests with symptoms such as orofacial pain, joint sounds and limited jaw movements. Our research group previously reported the functional necessity of a chemokine-chemokine receptor axis of CCL5-CCR5 in osteoclasts. Accumulated studies reported that this axis was involved in the pathogenesis of bone and joint destructive diseases, suggesting CCL5 as a potent biomarker. This study investigated whether or not the serum level of CCL5 can be a biomarker of DJD-TMJ and concomitantly analyzed changes in the serum and urine levels of bone markers to see whether or not changes in the rate of bone metabolism were predisposing. We enrolled 17 female subjects with diagnosed DJD-TMJ and sexually and age-matched 17 controls. The serum CCL5 level in DJD-TMJ subjects was significantly higher than that in the control subjects. Multivariate analyses indicated an association between an augmented CCL5 level and the rate of bone metabolism, especially in relatively young DJD-TMJ subjects without other systemic symptoms. A principal component analysis of serum markers and our pharmacological experiment using a postmenopausal model of ovariectomized rats suggested that an augmented serum CCL5 level specifically reflected DJD-TMJ and that covert changes in the rate of bone metabolism predisposed individuals to DJD-TMJ.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報	PMID 36769097
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijms24032775