Regioselective Deaminative Allylation of Aliphatic Amines via Dual Cobalt and Organophotoredox Catalysis

Sekino, Tomoyuki; Sato, Shunta; Yoshino, Tatsuhiko; Kojima, Masahiro; Matsunaga, Shigeki

Regioselective Deaminative Allylation of Aliphatic Amines via Dual Cobalt and Organophotoredox Catalysis

Sekino, Tomoyuki; Sato, Shunta; Yoshino, Tatsuhiko et al.

Organic letters, 2022, 24(11), 2120-2124

Permalink : https://hdl.handle.net/2115/88762

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アクセス権	open access
URI	https://hdl.handle.net/2115/88762
タイトル	Regioselective Deaminative Allylation of Aliphatic Amines via Dual Cobalt and Organophotoredox Catalysis
著者	Sekino, Tomoyuki ; Sato, Shunta ; Yoshino, Tatsuhiko ; Kojima, Masahiro ; Matsunaga, Shigeki
著者名 Sekino, Tomoyuki
著者名 Sato, Shunta
e-Rad_Researcher 50756179 著者名 Yoshino, Tatsuhiko
e-Rad_Researcher 90824714 著者名 Kojima, Masahiro
e-Rad_Researcher 50334339 著者名 Matsunaga, Shigeki
言語	英語
発行日	2022-03-09
出版者	American Chemical Society
収録物名	Organic letters
巻(号)	24(11)
ページ	2120-2124
抄録	Despite the rapid progress in C-C bond-forming reactions using Katritzky salts, their deaminative allylation remains a challenge. Inspired by the metallaphotoredox-catalyzed allylic substitution regime, here, we report the deaminative allylation of Katritzky salts via cobalt/organophotoredox dual catalysis. This cross-electrophile coupling enables regioselective allylation using a variety of allylic esters, overcoming the substrate limitations of reported protocols. Mechanistic studies indicate the involvement of a pi-allyl cobalt complex as a radicalophile that mediates C-C bond formation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-H4JCPXJAFRYRTCC68BPH.
PISSN	1523-7060
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.orglett.2c00319