Association of exposure to prenatal perfluoroalkyl substances and estrogen receptor 1 polymorphisms with the second to fourth digit ratio in school-aged children : The Hokkaido study

Nishimura, Yoko; Moriya, Kimihiko; Kobayashi, Sumitaka et al.

Reproductive toxicology, 2022, 109, 10-18

Permalink : https://hdl.handle.net/2115/88786

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/88786
タイトル
Association of exposure to prenatal perfluoroalkyl substances and estrogen receptor 1 polymorphisms with the second to fourth digit ratio in school-aged children : The Hokkaido study
著者
Nishimura, Yoko ; Moriya, Kimihiko ; Kobayashi, Sumitaka ; Ikeda-Araki, Atsuko ; Sata, Fumihiro ; Mitsui, Takahiko ; Itoh, Sachiko ; Miyashita, Chihiro ; Cho, Kazutoshi ; Kon, Masafumi ; Nakamura, Michiko ; Kitta, Takeya ; Murai, Sachiyo ; Kishi, Reiko ; Shinohara, Nobuo
著者名
Nishimura, Yoko
著者名
Moriya, Kimihiko
e-Rad_Researcher
10733371
著者名
Kobayashi, Sumitaka
著者名
Ikeda-Araki, Atsuko
著者名
Sata, Fumihiro
著者名
Mitsui, Takahiko
著者名
Itoh, Sachiko
著者名
Miyashita, Chihiro
著者名
Cho, Kazutoshi
著者名
Kon, Masafumi
著者名
Nakamura, Michiko
著者名
Kitta, Takeya
著者名
Murai, Sachiyo
e-Rad_Researcher
80112449
著者名
Kishi, Reiko
e-Rad_Researcher
90250422
著者名
Shinohara, Nobuo
言語
英語
キーワード
Per- and polyfluoroalkyl substances
ESR1 polymorphism & nbsp
Hand digit ratio
Birth cohort
Gene environment interaction
発行日
2022-04
出版者
Elsevier
収録物名
Reproductive toxicology
巻(号)
109
ページ
10-18
抄録
Per-and Polyfluoroalkyl substances (PFAS) have endocrine-disrupting effects. The ratio of the lengths of the second and fourth digits (2D:4D) is a noninvasive retrospective index of prenatal exposure to sex hormones, and estrogen receptor 1 (ESR1) polymorphisms may contribute to 2D:4D determination. We investigated whether ESR1 polymorphisms modify the effects of prenatal PFAS exposure on 2D:4D. Participants (n = 1024) with complete data in a prospective birth cohort study (the Hokkaido Study) were included, and maternal plasma in the third trimester was used to examine PFAS concentrations. 2D:4D was determined from photocopies of palms of children using Vernier calipers. ESR1 polymorphisms (rs2234693, rs9340799, and rs2077647) were genotyped by TaqMan polymerase chain reaction. PFAS and 2D:4D association with ESR1 polymorphisms was assessed by multiple linear regression adjusted for potential confounding factors. A 10-fold increase in maternal perfluorooctanoic acid (PFOA) concentration was associated with a 1.54% [95% confidence interval (CI): 0.40, 2.68] increase in mean 2D:4D in children with an AA genotype at rs9340799 and a 2.24% (95% CI: 0.57, 3.92) increase in children with an AA genotype at rs2077647. A 10-fold increase in perfluorododecanoic acid (PFDoDA) was associated with a significant increase in 2D:4D in children with the AA genotype [rs9340799, 1.18% (95% CI: 0.02, 2.34); and rs2077647, 1.67% (95% CI: 0.05, 3.28)]. These associations were apparent among males. A significant gene-environment interaction between PFOA or PFDoDA and ESR1 polymorphism was detected. These findings suggest that ESR1 polymorphisms modify the effects of prenatal exposure to PFAS on sex differentiation.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN
0890-6238
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.reprotox.2022.02.002