Transcriptional dynamics of granulocytes in direct response to incubation with SARS-CoV-2

Nakazawa, Daigo; Takeda, Yohei; Kanda, Masatoshi et al.

Febs open bio, 2023, 13(1), 60-71

Permalink : https://hdl.handle.net/2115/88791

このアイテムのアクセス数:313件（2026-01-17 00:19 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
https://doi.org/10.1002/2211-5463.13500      

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
metadata only access
URI
https://hdl.handle.net/2115/88791
タイトル
Transcriptional dynamics of granulocytes in direct response to incubation with SARS-CoV-2
著者
Nakazawa, Daigo ; Takeda, Yohei ; Kanda, Masatoshi ; Tomaru, Utano ; Ogawa, Haruko ; Kudo, Takashi ; Shiratori-Aso, Satoka ; Watanabe-Kusunoki, Kanako ; Ueda, Yusho ; Miyoshi, Atsuko ; Hattanda, Fumihiko ; Nishio, Saori ; Uozumi, Ryo ; Ishizu, Akihiro ; Atsumi, Tatsuya
e-Rad_Researcher
60724135
著者名
Nakazawa, Daigo
著者名
Takeda, Yohei
著者名
Kanda, Masatoshi
著者名
Tomaru, Utano
著者名
Ogawa, Haruko
著者名
Kudo, Takashi
著者名
Shiratori-Aso, Satoka
著者名
Watanabe-Kusunoki, Kanako
著者名
Ueda, Yusho
著者名
Miyoshi, Atsuko
著者名
Hattanda, Fumihiko
著者名
Nishio, Saori
著者名
Uozumi, Ryo
著者名
Ishizu, Akihiro
e-Rad_Researcher
20301905
著者名
Atsumi, Tatsuya
言語
英語
キーワード
granulocytes
low-density granulocytes
neutrophil extracellular traps
SARS-CoV-2
severe COVID-19
発行日
2023-01
出版者
John Wiley & Sons
収録物名
Febs open bio
巻(号)
13(1)
ページ
60-71
抄録
Severe coronavirus disease 2019 (COVID-19) is characterized by acute respiratory distress syndrome and multiple organ dysfunction, in which the host immune response plays a pivotal role. Excessive neutrophil activation and subsequent superfluity of neutrophil extracellular traps (NETs) can lead to tissue damage, and several studies have shown the involvement of neutrophils in severe COVID-19. However, the detailed responses of each neutrophil subset to SARS-CoV-2 infection has not been fully described. To explore this issue, we incubated normal-density granulocytes (NDGs) and low-density granulocytes (LDGs) with different viral titers of SARS-CoV-2. NDGs form NETs with chromatin fibers in response to SARS-CoV-2, whereas LDGs incubated with SARS-CoV-2 display a distinct morphology with condensed nuclei and moderate transcriptional changes. Based on these transcriptional changes, we suggest that AGO2 possibly plays a role in LDG regulation in response to SARS-CoV-2.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
2211-5463
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1002/2211-5463.13500