Potential determinants of T helper 2 markers and their distribution in school-aged children

Goudarzi, Houman; Ikeda-Araki, Atsuko; Bamai, Yu Ait; Ito, Sachiko; Inao, Tasuku; Yokota, Isao; Miyashita, Chihiro; Kishi, Reiko; Konno, Satoshi

Potential determinants of T helper 2 markers and their distribution in school-aged children

Goudarzi, Houman; Ikeda-Araki, Atsuko; Bamai, Yu Ait et al.

Allergology international, 2023, 72(1), 100-106

Permalink : https://hdl.handle.net/2115/88851

このアイテムのアクセス数:312件（2026-05-20 06:55 集計）

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https://doi.org/10.1016/j.alit.2022.07.009			4

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/88851
タイトル	Potential determinants of T helper 2 markers and their distribution in school-aged children
著者	Goudarzi, Houman ; Ikeda-Araki, Atsuko ; Bamai, Yu Ait ; Ito, Sachiko ; Inao, Tasuku ; Yokota, Isao ; Miyashita, Chihiro ; Kishi, Reiko ; Konno, Satoshi
e-Rad_Researcher 40713607 著者名 Goudarzi, Houman
e-Rad_Researcher 00619885 著者名 Ikeda-Araki, Atsuko
e-Rad_Researcher 90752907 著者名 Bamai, Yu Ait
著者名 Ito, Sachiko
著者名 Inao, Tasuku
著者名 Yokota, Isao
著者名 Miyashita, Chihiro
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
言語	英語
キーワード	Childhood allergies
	Pre-and post-natal factors
	Prospective birth cohort
	School-age children
	T helper 2 biomarkers
発行日	2023-01
出版者	Japanese Society Allergology
収録物名	Allergology international
巻(号)	72(1)
ページ	100-106
抄録	Background: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 bio-markers, including blood eosinophils, FeNO, and serum total IgE in 9-11-year-old children in a pro-spective birth cohort.Methods: We examined the pre-and postnatal factors associated with Th2 biomarkers using multivar-iable logistic regression analysis (n = 428) and extended the results to the original cohort (n = 17,009) using inverse probability weighting. We also measured typical Th2 biomarker distribution in all exam-ined children and healthy participants without allergic diseases (n = 180).Results: At age 9-11, wheeze (odds ratio (OR) 7.63), rhinitis (OR 3.14), and eczema (OR 2.46) were significantly associated with increased blood eosinophils. All three allergic conditions were associated with FeNO and total serum IgE, but the ORs were smaller than those for blood eosinophils. Secondhand smoking was inversely associated with the blood eosinophils (OR, 0.38). Similar results were found in the original cohort. Male sex and prenatal factors (maternal smoking and parental history of allergies) were not independent predictors of high Th2 levels.Conclusions: In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are inde-pendent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be applicable to children.(c) 2022 Japanese Society of Allergology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1323-8930
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.alit.2022.07.009