Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments

Endo, Tsutomu; Takahata, Masahiko; Fujita, Ryo; Koike, Yoshinao; Suzuki, Ryota; Hasegawa, Yuichi; Murakami, Toshifumi; Ishii, Misaki; Yamada, Katsuhisa; Sudo, Hideki; Iwasaki, Norimasa

Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments

Endo, Tsutomu; Takahata, Masahiko; Fujita, Ryo et al.

Scientific reports, 2022, 12(1), 22617

Permalink : https://hdl.handle.net/2115/88917

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アクセス権	open access
URI	https://hdl.handle.net/2115/88917
タイトル	Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments
著者	Endo, Tsutomu ; Takahata, Masahiko ; Fujita, Ryo ; Koike, Yoshinao ; Suzuki, Ryota ; Hasegawa, Yuichi ; Murakami, Toshifumi ; Ishii, Misaki ; Yamada, Katsuhisa ; Sudo, Hideki ; Iwasaki, Norimasa
e-Rad_Researcher 90805293 著者名 Endo, Tsutomu
著者名 Takahata, Masahiko
著者名 Fujita, Ryo
著者名 Koike, Yoshinao
著者名 Suzuki, Ryota
著者名 Hasegawa, Yuichi
著者名 Murakami, Toshifumi
著者名 Ishii, Misaki
著者名 Yamada, Katsuhisa
e-Rad_Researcher 30374367 著者名 Sudo, Hideki
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
言語	英語
発行日	2022-12-30
出版者	Nature Portfolio
収録物名	Scientific reports
巻(号)	12(1)
ページ	22617
抄録	Obesity and metabolic disturbances are prevalent in ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF); however, the involvement of dyslipidemia (DL) in OPLL/OLF remains uncertain. We investigated the association between dyslipidemia and OPLL/OLF using a dataset of 458 individuals receiving health screening tests, including computed tomography. Subjects were grouped according to the presence or location of OPLL/OLF: controls (no OPLL/OLF, n=230), OLF (n=167), cervical OPLL (n=28), and thoracic OPLL (n=33). They were also grouped according to the presence of dyslipidemia (DL[+], n=215; DL[-], n=243). The proportion of dyslipidemia in the OLF and OPLL groups was 1.6-2.2 times higher than that in the control group. The proportion of OLF and OPLL in the DL(+) group was significantly higher than that in the DL(-) group (OLF, 43% vs. 29%; cervical OPLL, 14.4% vs. 3.2%; thoracic OPLL, 11.1% vs. 3.7%). Multivariate logistic regression analysis showed an association between all ossification types and dyslipidemia. This study demonstrated an association of dyslipidemia with OPLL/OLF; further investigation on the causal relationship between dyslipidemia and ectopic spinal ligament ossification is warranted to develop a therapeutic intervention for OPLL/OLF.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2045-2322
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-022-27136-4