Efficacy of Quantitative Susceptibility Mapping with Brain Surface Correction and Vein Removal for Detecting Increase Magnetic Susceptibility in Patients with Alzheimer's Disease

Yamaguchi, Akinori; Kudo, Kohsuke; Sato, Ryota et al.

Magnetic resonance in medical sciences, 2023, 22(1), 87-94

Permalink : https://hdl.handle.net/2115/88924

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https://doi.org/10.2463/mrms.mp.2021-0015     1

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アクセス権
metadata only access
URI
https://hdl.handle.net/2115/88924
タイトル
Efficacy of Quantitative Susceptibility Mapping with Brain Surface Correction and Vein Removal for Detecting Increase Magnetic Susceptibility in Patients with Alzheimer's Disease
著者
Yamaguchi, Akinori ; Kudo, Kohsuke ; Sato, Ryota ; Kawata, Yasuo ; Udo, Niki ; Matsushima, Masaaki ; Yabe, Ichiro ; Sasaki, Makoto ; Harada, Masafumi ; Matsukawa, Noriyuki ; Shirai, Toru ; Ochi, Hisaaki ; Bito, Yoshitaka
著者名
Yamaguchi, Akinori
e-Rad_Researcher
10374232
著者名
Kudo, Kohsuke
著者名
Sato, Ryota
著者名
Kawata, Yasuo
著者名
Udo, Niki
著者名
Matsushima, Masaaki
著者名
Yabe, Ichiro
著者名
Sasaki, Makoto
著者名
Harada, Masafumi
著者名
Matsukawa, Noriyuki
著者名
Shirai, Toru
著者名
Ochi, Hisaaki
著者名
Bito, Yoshitaka
言語
英語
キーワード
Alzheimer?s disease
brain surface correction
cerebral cortex
quantitative susceptibility mapping
vein removal
発行日
2023
出版者
Japanese Society for Magnetic Resonance in Medicine
収録物名
Magnetic resonance in medical sciences
巻(号)
22(1)
ページ
87-94
抄録
Purpose: Studies on quantitative susceptibility mapping (QSM) have reported an increase in magnetic susceptibilities in patients with Alzheimer's disease (AD). Despite the pathological importance of the brain surface areas, they are sometimes excluded in QSM analysis. This study aimed to reveal the efficacy of QSMMethods: Thirty-seven AD patients and 37 age- and sex-matched, cognitively normal (CN) subjects were included. A 3D-gradient echo sequence at 3T MRI was used to obtain QSM. QSM images were created with regularization enabled sophisticated harmonic artifact reduction for phase data (RESHARP) and constrained RESHARP with BSC and/or VR. We conducted ROI analysis between AD patients and CN subjects who did or did not undergo BSC and/or VR using a t-test, to compare the susceptibility values after gray matter weighting. Results: The susceptibility values in RESHARP without BSC were significantly larger in AD patients than in CN subjects in one region (precentral gyrus, 8.1 +/- 2.9 vs. 6.5 +/- 2.1 ppb) without VR and one region with VR (precentral gyrus, 7.5 +/- 2.8 vs. 5.9 +/- 2.0 ppb). Three regions in RESHARP with BSC had significantly larger susceptibilities without VR (precentral gyrus, 7.1 +/- 2.0 vs. 5.9 +/- 2.0 ppb; superior medial frontal gyrus, 5.7 +/- 2.6 vs. 4.2 +/- 3.1 ppb; putamen, 47,8 +/- 16.5 vs. 40.0 +/- 15.9 ppb). In contrast, six regions showed significantly larger susceptibilities with VR in AD patients than in CN subjects (precentral gyrus, 6.4 +/- 1.9 vs. 4.9 +/- 2.7 ppb; superior medial frontal gyrus, 5.3 +/- 2.7 vs. 3.7 +/- 3.3 ppb; orbitofrontal cortex, -2.1 +/- 2.7 vs. -3.6 +/- 3.2 ppb; parahippocampal gyrus, 0.1 +/- 3.6 vs. -1.7 +/- 3.7 ppb; putamen, 45.0 +/- 14.9 vs. 37.6 +/- 14.6 ppb; inferior temporal gyrus, -3.4 +/- 1.5 vs. -4.4 +/- 1.5 ppb).Conclusion: RESHARP with BSC and VR showed more regions of increased susceptibility in AD patients than in CN subjects. This study highlights the efficacy of this method in facilitating the diagnosis of AD.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1347-3182
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.2463/mrms.mp.2021-0015