Transcranial direct current stimulation to the left dorsolateral prefrontal cortex enhances early dexterity skills with the left non-dominant hand : a randomized controlled trial

Watanabe, Akihiro; Sawamura, Daisuke; Nakazono, Hisato; Tokikuni, Yukina; Miura, Hiroshi; Sugawara, Kazuhiro; Fuyama, Kanako; Tohyama, Harukazu; Yoshida, Susumu; Sakai, Shinya

Transcranial direct current stimulation to the left dorsolateral prefrontal cortex enhances early dexterity skills with the left non-dominant hand : a randomized controlled trial

Watanabe, Akihiro; Sawamura, Daisuke; Nakazono, Hisato et al.

Journal of Translational Medicine, 2023, 21(1), 143

Permalink : https://hdl.handle.net/2115/88946

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https://doi.org/10.1186/s12967-023-03989-9

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/88946
タイトル	Transcranial direct current stimulation to the left dorsolateral prefrontal cortex enhances early dexterity skills with the left non-dominant hand : a randomized controlled trial
著者	Watanabe, Akihiro ; Sawamura, Daisuke ; Nakazono, Hisato ; Tokikuni, Yukina ; Miura, Hiroshi ; Sugawara, Kazuhiro ; Fuyama, Kanako ; Tohyama, Harukazu ; Yoshida, Susumu ; Sakai, Shinya
著者名 Watanabe, Akihiro
e-Rad_Researcher 20734750 著者名 Sawamura, Daisuke
著者名 Nakazono, Hisato
著者名 Tokikuni, Yukina
著者名 Miura, Hiroshi
著者名 Sugawara, Kazuhiro
著者名 Fuyama, Kanako
e-Rad_Researcher 60301884 著者名 Tohyama, Harukazu
著者名 Yoshida, Susumu
e-Rad_Researcher 30299804 著者名 Sakai, Shinya
言語	英語
キーワード	Transcranial direct current stimulation
	Motor learning
	Dorsolateral prefrontal cortex
	Non-dominant hand
	Fine motor
	Cognitive aspects
発行日	2023-02-24
出版者	BioMed Central
収録物名	Journal of Translational Medicine
巻(号)	21(1)
ページ	143
抄録	Background The left dorsolateral prefrontal cortex (DLPFC) is involved in early-phase manual dexterity skill acquisition when cognitive control processes, such as integration and complexity demands, are required. However, the effectiveness of left DLPFC transcranial direct current stimulation (tDCS) on early-phase motor learning and whether its effectiveness depends on the cognitive demand of the target task are unclear. This study aimed to investigate whether tDCS over the left DLPFC improves non-dominant hand dexterity performance and determine if its efficacy depends on the cognitive demand of the target task.Methods In this randomized, double-blind, sham-controlled trial, 70 healthy, right-handed, young adult participants were recruited. They were randomly allocated to the active tDCS (2 mA for 20 min) or sham groups and repeatedly performed the Purdue Pegboard Test (PPT) left-handed peg task and left-handed assembly task three times: pre-tDCS, during tDCS, and post tDCS.Results The final sample comprised 66 healthy young adults (mean age, 22.73 +/- 1.57 years). There were significant interactions between group and time in both PPT tasks, indicating significantly higher performance of those in the active tDCS group than those in the sham group post tDCS (p < 0.001). Moreover, a greater benefit was observed in the left-handed assembly task performance than in the peg task performance (p < 0.001). No significant correlation between baseline performance and benefits from tDCS was observed in either task.Conclusions These results demonstrated that prefrontal tDCS significantly improved early-phase manual dexterity skill acquisition, and its benefits were greater for the task with high cognitive demands. These findings contribute to a deeper understanding of the underlying neurophysiological mechanisms of the left DLPFC in the modulation of early-phase dexterity skill acquisition.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
EISSN	1479-5876
関連情報	PMID 36823635
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12967-023-03989-9