open access

https://hdl.handle.net/2115/89037

Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent

英語

adjacent sequence

2022-10-10

National Academy of Sciences.

Proceedings of the National Academy of Sciences of the United States of America (PNAS)

119(42)

e2206685119

Liquid embolic agents are widely used for the endovascular embolization of vascular conditions. However, embolization based on phase transition is limited by the adhesion of the microcatheter to the embolic agent, use of an organic solvent, unintentional catheter retention, and other complications. By mimicking thrombus formation, a water-soluble polymer that rapidly glues blood into a gel without triggering coagulation was developed. The polymer, which consists of cationic and aromatic residues with adjacent sequences, shows electrostatic adhesion with negatively charged blood substances in a physiological environment, while common polycations cannot. Aqueous polymer solutions are injectable through clinical microcatheters and needles. The formed blood gel neither adhered to the catheter nor blocked the port. Postoperative computed tomography imaging showed that the polymer can block the rat femoral artery in vivo and remain at the injection site without nontarget embolization. This study provides an alternative for the development of waterborne embolic agents.

学術雑誌論文

Version of Record

0027-8424