Oocyte cumulus complex quality and oviduct transportation velocity in systemic autoimmune disease model mice

Hosotani, Marina; Ichii, Osamu; Watanabe, Takafumi et al.

Experimental biology and medicine, 2023

Permalink : https://hdl.handle.net/2115/89167

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/89167
タイトル
Oocyte cumulus complex quality and oviduct transportation velocity in systemic autoimmune disease model mice
著者
Hosotani, Marina ; Ichii, Osamu ; Watanabe, Takafumi ; Kon, Yasuhiro
著者名
Hosotani, Marina
e-Rad_Researcher
60547769
著者名
Ichii, Osamu
著者名
Watanabe, Takafumi
e-Rad_Researcher
10178402
著者名
Kon, Yasuhiro
言語
英語
キーワード
Autoimmune disease
cumulus cell
cilia
ex vivo experiment
oocyte transportation
oviduct
発行日
2023-03-24
出版者
SAGE Publications
収録物名
Experimental biology and medicine
抄録
Oocyte transportation by the oviduct involves the interaction between ciliated epithelial cells and cumulus cells. To determine whether the quality of cumulus-oocyte complexes (COCs) changes the transportation property of COCs, we compared the transportation velocity of COCs (TVC) by the infundibulum ex vivo with various combinations of infundibula and COCs collected from different mice. We used young and aged C57BL/6N and MRL/MpJ, and MRL/MpJ-Fas (lpr/lpr) mice as the strains with intact female reproductive function and the systemic autoimmune disease model exhibiting oocyte pick-up dysfunction owing to the morphofunctional abnormality of ciliated epithelium, respectively. The TVC of aged MRL strains was less than that of aged C57BL/6N mice, suggesting that aging affects the transportation of COCs in MRL strains. The TVC of aged MRL/MpJ-Fas( lpr/lpr ) mice was the least among all examined combinations, whereas the TVC accelerated when the infundibulum or COCs were collected from other strains. These results indicate that the transportation property of COCs is determined not only by the ciliary function in the infundibulum but also by the properties of COCs.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Hosotani M, Ichii O, Watanabe T, Kon Y. Oocyte cumulus complex quality and oviduct transportation velocity in systemic autoimmune disease model mice. Experimental Biology and Medicine. Copyright © 2023. doi:10.1177/15353702231160875
PISSN
1535-3702
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1177/15353702231160875