open access

https://doi.org/10.14943/doctoral.k13040

https://hdl.handle.net/2115/89195

骨形成の促進を目的としたカーボンナノホーンによる陽極酸化チタンの表面修飾

英語

2018-03-22

Hokkaido University

Carbon nanohorn (CNH) is a rolled graphene like circular cone. Recently, we reported that CNHs can promote bone formation in the early stage of bone healing process. These results suggested that CNHs are promising for surface modification of dental implant materials which accelerate the osseointegration. In this study, the anodized titanium (AnTi) coated with CNHs (CNH/AnTi) was developed in order to accelerate osseointegration and AnTi covered with CNHs was obtained without undesired formation of large aggregates by using the electrodeposition technique with applied potential at 300V for 180 s. CNH/AnTi improved the osteoblast-like cell proliferation, while it did not have an effect on the differentiation for osteoblast-like cell. 7 days after implantation of CNH/AnTi in rat femur, more amount of bone formed on the surface compared to AnTi. In addition, certain parts of new bone tissue were contacted with CNHs directly. The implant coated with CNHs by electrodeposition demonstrated excellent biocompatibility with bone tissues and promoted osseointegration in early stage.

2018-03-22

甲第13040号

博士(歯学)

(主査) 教授 横山 敦郎, 教授 網塚 憲生, 教授 吉田 靖弘

歯学研究科（口腔医学専攻）

博士論文

Version of Record