Secondhand Smoke Exposure During Childhood and Cancer Mortality in Adulthood Among Never Smokers : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk

Teramoto, Masayuki; Iso, Hiroyasu; Wakai, Kenji et al.

American Journal of Epidemiology, 2022, 191(5), 834-842

Permalink : https://hdl.handle.net/2115/89280

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/89280
タイトル
Secondhand Smoke Exposure During Childhood and Cancer Mortality in Adulthood Among Never Smokers : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk
著者
Teramoto, Masayuki ; Iso, Hiroyasu ; Wakai, Kenji ; Tamakoshi, Akiko
著者名
Teramoto, Masayuki
著者名
Iso, Hiroyasu
著者名
Wakai, Kenji
e-Rad_Researcher
90236737
著者名
Tamakoshi, Akiko
言語
英語
キーワード
cancer mortality
parental smoking
passive smoking
secondhand smoke
発行日
2022-05-01
出版者
Oxford University Press
収録物名
American Journal of Epidemiology
巻(号)
191(5)
ページ
834-842
抄録
We examined whether secondhand smoke exposure during childhood was associated with cancer mortality in adulthood among never smokers. In the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, we analyzed data from 45,722 Japanese lifetime nonsmokers aged 40-79 years with no history of cancer at baseline (1988-1990) who had completed a lifestyle questionnaire, including information on the number of family members who had smoked at home during their childhood (0, 1, 2, or >= 3 family members). A Cox proportional hazards model and competing-risks regression were used to calculate multivariable hazard ratios and subdistribution hazard ratios with 95% confidence intervals for overall and site-specific cancer mortality according to the number of family members who smoked during the participant's childhood, after adjusting for potentially confounding factors. During a median follow-up period of 19.2 years, a total of 2,356 cancer deaths were documented. Secondhand smoke exposure was positively associated with the risk of mortality from pancreatic cancer in adulthood; the multivariable hazard ratio for having 3 or more family members who smoked (as compared with none) was 2.32 (95% confidence interval: 1.14, 4.72). Associations were not evident for total cancer risk or risk of other types of smoking-related cancer. In this study, secondhand smoke exposure during childhood was associated with an increased risk of pancreatic cancer mortality in adulthood.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Epidemiology following peer review. The version of record Masayuki Teramoto, Hiroyasu Iso, Kenji Wakai, Akiko Tamakoshi, Secondhand Smoke Exposure During Childhood and Cancer Mortality in Adulthood Among Never Smokers: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk, American Journal of Epidemiology, Volume 191, Issue 5, May 2022, Pages 834–842 is available online at: https://doi.org/10.1093/aje/kwab284
PISSN
0002-9262
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1093/aje/kwab284