Impact of right ventricular reserve on exercise capacity and quality of life in patients with left ventricular assist device

Takenaka, Sakae; Sato, Takuma; Nagai, Toshiyuki et al.

American journal of physiology. Heart and circulatory physiology, 2023, 324(3), H355-H363

Permalink : https://hdl.handle.net/2115/89314

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https://doi.org/10.1152/ajpheart.00626.2022     1

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アクセス権
metadata only access
URI
https://hdl.handle.net/2115/89314
タイトル
Impact of right ventricular reserve on exercise capacity and quality of life in patients with left ventricular assist device
著者
Takenaka, Sakae ; Sato, Takuma ; Nagai, Toshiyuki ; Omote, Kazunori ; Kobayashi, Yuta ; Kamiya, Kiwamu ; Konishi, Takao ; Tada, Atsushi ; Mizuguchi, Yoshifumi ; Takahashi, Yuki ; Naito, Seiichiro ; Saiin, Kohei ; Ishizaka, Suguru ; Wakasa, Satoru ; Anzai, Toshihisa
著者名
Takenaka, Sakae
著者名
Sato, Takuma
e-Rad_Researcher
00528218
著者名
Nagai, Toshiyuki
著者名
Omote, Kazunori
著者名
Kobayashi, Yuta
著者名
Kamiya, Kiwamu
著者名
Konishi, Takao
著者名
Tada, Atsushi
著者名
Mizuguchi, Yoshifumi
著者名
Takahashi, Yuki
著者名
Naito, Seiichiro
著者名
Saiin, Kohei
著者名
Ishizaka, Suguru
e-Rad_Researcher
10374365
著者名
Wakasa, Satoru
e-Rad_Researcher
60232089
著者名
Anzai, Toshihisa
言語
英語
キーワード
exercise capacity
health-related quality of life
left ventricular assist device
right ventricular reserve
発行日
2023-03
出版者
American Physiological Society
収録物名
American journal of physiology. Heart and circulatory physiology
巻(号)
324(3)
ページ
H355-H363
抄録
Although measuring right ventricular (RV) function during exercise is more informative than assessing it at rest, the relationship between RV reserve function, exercise capacity, and health-related quality of life (HRQoL) in patients with left ventricular assist devices (LVAD) remains unresolved. We aimed to investigate whether RV reserve assessed by the change in RV stroke work index (RVSWI) during exercise is correlated with exercise capacity and HRQoL in patients with LVAD. We prospectively assessed 24 consecutive patients with LVAD who underwent invasive right heart catheterization in the supine position. Exercise capacity and HRQoL were assessed using the 6-min walk distance (6 MWD) and peak oxygen consumption (V_ O2) in cardiopulmonary exercise testing, and the EuroQol visual analog scale (EQ-VAS), respectively. The patients were divided into two groups according to the median ARVSWI (change from rest to peak exercise). Patients with lower ARVSWI had significantly lower changes in cardiac index and absolute value of RV dP/dt than those with higher ARVSWI. The ARVSWI was positively correlated with 6 MWD (r = 0.59, P = 0.003) and peak V_ O2 (r = 0.56, P = 0.006). In addition, ARVSWI was positively correlated with the EQ-VAS (r = 0.44, P = 0.030). In contrast, there was no significant correlation between RVSWI at rest and 6 MWD (r = -0.34, P = 0.88), peak V_ O2 (r = 0.074, P = 0.74), or EQ-VAS (r = 0.127, P = 0.56). Our findings suggest that the assessment of RV reserve function is useful for risk stratification in patients with LVAD. NEW & NOTEWORTHY The change in right ventricular stroke work index (RVSWI) during exercise, not RVSWI at rest, was associated with exercise capacity and HRQoL. Our findings suggest that the assessment of change in RVSWI during exercise as a surrogate of RV reserve function may aid in risk stratification of patients with LVAD.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0363-6135
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1152/ajpheart.00626.2022