Ablation of microglia does not alter circadian rhythm of locomotor activity

Matsui, Futaba; Yamaguchi, Sho T. T.; Kobayashi, Riho et al.

Molecular brain, 2023, 16(1), 34

Permalink : https://hdl.handle.net/2115/89316

このアイテムのアクセス数:328件（2026-01-23 07:25 集計）

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https://doi.org/10.1186/s13041-023-01021-1      

論文情報

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アクセス権
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URI
https://hdl.handle.net/2115/89316
タイトル
Ablation of microglia does not alter circadian rhythm of locomotor activity
著者
Matsui, Futaba ; Yamaguchi, Sho T. T. ; Kobayashi, Riho ; Ito, Shiho ; Nagashima, Sakimi ; Zhou, Zhiwen ; Norimoto, Hiroaki
著者名
Matsui, Futaba
著者名
Yamaguchi, Sho T. T.
著者名
Kobayashi, Riho
著者名
Ito, Shiho
著者名
Nagashima, Sakimi
著者名
Zhou, Zhiwen
著者名
Norimoto, Hiroaki
言語
英語
キーワード
Microglia
Circadian rhythm
Suprachiasmatic nucleus
発行日
2023-04-07
出版者
BioMed Central
収録物名
Molecular brain
巻(号)
16(1)
ページ
34
抄録
Microglia, as macrophages in the brain, are responsible for immune responses and synaptic remodeling. Although the function of microglia is regulated by circadian rhythms, it is still unclear whether microglia are involved in the generation and light entrainment of circadian rhythms of behavior. Here, we report that microglial depletion does not alter behavioral circadian rhythms. We depleted similar to 95% of microglia in the mouse brain by PLX3397, a CSF1R inhibitor, and analyzed the effect on the spontaneous behaviors of mice. We found that neither the free-running period under constant darkness nor light entrainment under jet-lag circumstances were influenced by the ablation of microglia. Our results demonstrate that the circadian rhythms of locomotor activity, an important output of the circadian clock in the brain, are likely a phenomenon not produced by microglia.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s13041-023-01021-1