Raman imaging of rat nonalcoholic fatty liver tissues reveals distinct biomolecular states

Helal, Khalifa Mohammad; Cahyadi, Harsono; Taylor, J. Nicholas; Okajima, Akira; Tabata, Koji; Kumamoto, Yasuaki; Mochizuki, Kentaro; Itoh, Yoshito; Takamatsu, Tetsuro; Tanaka, Hideo; Fujita, Katsumasa; Komatsuzaki, Tamiki; Harada, Yoshinori

Raman imaging of rat nonalcoholic fatty liver tissues reveals distinct biomolecular states

Helal, Khalifa Mohammad; Cahyadi, Harsono; Taylor, J. Nicholas et al.

FEBS Letters, 2023, 597(11), 1517-1527

Permalink : https://hdl.handle.net/2115/89747

このアイテムのアクセス数:944件（2026-01-16 06:43 集計）

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https://doi.org/10.1002/1873-3468.14600

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/89747
タイトル	Raman imaging of rat nonalcoholic fatty liver tissues reveals distinct biomolecular states
著者	Helal, Khalifa Mohammad ; Cahyadi, Harsono ; Taylor, J. Nicholas ; Okajima, Akira ; Tabata, Koji ; Kumamoto, Yasuaki ; Mochizuki, Kentaro ; Itoh, Yoshito ; Takamatsu, Tetsuro ; Tanaka, Hideo ; Fujita, Katsumasa ; Komatsuzaki, Tamiki ; Harada, Yoshinori
著者名 Helal, Khalifa Mohammad
著者名 Cahyadi, Harsono
著者名 Taylor, J. Nicholas
著者名 Okajima, Akira
著者名 Tabata, Koji
著者名 Kumamoto, Yasuaki
著者名 Mochizuki, Kentaro
著者名 Itoh, Yoshito
著者名 Takamatsu, Tetsuro
著者名 Tanaka, Hideo
著者名 Fujita, Katsumasa
e-Rad_Researcher 30270549 著者名 Komatsuzaki, Tamiki
著者名 Harada, Yoshinori
言語	英語
キーワード	nonalcoholic fatty liver
	nonalcoholic fatty liver disease
	nonalcoholic steatohepatitis
	Raman imaging
発行日	2023-02-17
出版者	John Wiley & Sons
収録物名	FEBS Letters
巻(号)	597(11)
ページ	1517-1527
抄録	An essential challenge in diagnosing states of nonalcoholic fatty liver disease (NAFLD) is the early prediction of progression from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) before the disease progresses. Histological diagnoses of NAFLD rely on the appearance of anomalous tissue morphologies, and it is difficult to segment the biomolecular environment of the tissue through a conventional histopathological approach. Here, we show that hyperspectral Raman imaging provides diagnostic information on NAFLD in rats, as spectral changes among disease states can be detected before histological characteristics emerge. Our results demonstrate that Raman imaging of NAFLD can be a useful tool for histopathologists, offering biomolecular distinctions among tissue states that cannot be observed through standard histopathological means.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0014-5793
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/1873-3468.14600