Emerging functions and clinical applications of exosomal microRNAs in diseases

Ghafouri-Fard, Soudeh; Shoorei, Hamed; Dong, Peixin; Poornajaf, Yadollah; Hussen, Bashdar Mahmud; Taheri, Mohammad; Akbari Dilmaghani, Nader

Emerging functions and clinical applications of exosomal microRNAs in diseases

Ghafouri-Fard, Soudeh; Shoorei, Hamed; Dong, Peixin et al.

Non-coding RNA Research, 2023, 8(3), 350-362

Permalink : https://hdl.handle.net/2115/89784

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/89784
タイトル	Emerging functions and clinical applications of exosomal microRNAs in diseases
著者	Ghafouri-Fard, Soudeh ; Shoorei, Hamed ; Dong, Peixin ; Poornajaf, Yadollah ; Hussen, Bashdar Mahmud ; Taheri, Mohammad ; Akbari Dilmaghani, Nader
著者名 Ghafouri-Fard, Soudeh
著者名 Shoorei, Hamed
e-Rad_Researcher 50602504 著者名 Dong, Peixin
著者名 Poornajaf, Yadollah
著者名 Hussen, Bashdar Mahmud
著者名 Taheri, Mohammad
著者名 Akbari Dilmaghani, Nader
言語	英語
キーワード	Exosome
	miRNA
	Cancer
	Neurological disorders
	Cardiovascular disorders
	Gastrointestinal disorders
発行日	2023-09
出版者	Elsevier
収録物名	Non-coding RNA Research
巻(号)	8(3)
ページ	350-362
抄録	Exosomes are an important group of extracellular vesicles that transfer several kinds of biomolecules and facilitate cell-cell communication. The content of exosomes, particularly the amounts of microRNA (miRNAs) inside these vesicles, demonstrates a disease-specific pattern reflecting pathogenic processes and may be employed as a diagnostic and prognostic marker. miRNAs may enter recipient cells through exosomes and generate a RISC complex that can cause degradation of the target mRNAs or block translation of their corresponding proteins. Therefore, exosome-derived miRNAs constitute an important mechanism of gene regulation in recipient cells. The miRNA content of exosomes can be used as an important tool in the detection of diverse disorders, particularly cancers. This research field has an important situation in cancer diagnosis. In addition, exosomal microRNAs offer a great deal of promise in the treatment of human disorders. However, there are still certain challenges to be resolved. The most important challenges are as follow: the detection of exosomal miRNAs should be standardized, exosomal miRNAs-associated studies should be conducted in large number of clinical samples, and experiment settings and detection criteria should be consistent across different labs. The goal of this article is to present an overview of the effects of exosome-derived microRNAs on a variety of diseases, including gastrointestinal, pulmonary, neurological, and cardiovascular diseases, with a particular emphasis on malignancies.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2468-0540
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.ncrna.2023.05.004