Further evidence for association of YKL-40 with severe asthma airway remodeling

Kimura, Hirokazu; Shimizu, Kaoruko; Tanabe, Naoya et al.

Annals of Allergy, Asthma & Immunology, 2022, 128(6), 682-688.e5

Permalink : https://hdl.handle.net/2115/89790

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アクセス権
open access
URI
https://hdl.handle.net/2115/89790
タイトル
Further evidence for association of YKL-40 with severe asthma airway remodeling
著者
Kimura, Hirokazu ; Shimizu, Kaoruko ; Tanabe, Naoya ; Makita, Hironi ; Taniguchi, Natsuko ; Kimura, Hiroki ; Suzuki, Masaru ; Abe, Yuki ; Matsumoto-Sasaki, Machiko ; Oguma, Akira ; Takimoto-Sato, Michiko ; Takei, Nozomu ; Matsumoto, Munehiro ; Goudarzi, Houman ; Sato, Susumu ; Ono, Junya ; Izuhara, Kenji ; Hirai, Toyohiro ; Nishimura, Masaharu ; Konno, Satoshi
e-Rad_Researcher
90789330
著者名
Kimura, Hirokazu
e-Rad_Researcher
40399853
著者名
Shimizu, Kaoruko
著者名
Tanabe, Naoya
著者名
Makita, Hironi
著者名
Taniguchi, Natsuko
著者名
Kimura, Hiroki
著者名
Suzuki, Masaru
著者名
Abe, Yuki
著者名
Matsumoto-Sasaki, Machiko
著者名
Oguma, Akira
著者名
Takimoto-Sato, Michiko
著者名
Takei, Nozomu
著者名
Matsumoto, Munehiro
著者名
Goudarzi, Houman
著者名
Sato, Susumu
著者名
Ono, Junya
著者名
Izuhara, Kenji
著者名
Hirai, Toyohiro
e-Rad_Researcher
00208224
著者名
Nishimura, Masaharu
e-Rad_Researcher
20399835
著者名
Konno, Satoshi
言語
英語
発行日
2022-06
出版者
Elsevier
収録物名
Annals of Allergy, Asthma & Immunology
巻(号)
128(6)
ページ
682-688.e5
抄録
Background: The chitinase-like protein YKL-40 is associated with airflow limitation on spirometry and airway remodeling in patients with asthma. It remains unclear whether YKL-40 is associated with morphologic changes in the airways and parenchyma or with future progression of airflow limitation in severe asthma. Objective: To evaluate the association of circulating YKL-40 levels with morphologic changes in the airways and parenchyma and with longitudinal progression of airflow limitation. Methods: The patients were participants in the Hokkaido Severe Asthma Cohort Study (n = 127), including smokers. This study consisted of 2 parts. In analysis 1, we analyzed associations between circulating YKL-40 levels and several asthma-related indices, including computed tomography-derived indices of proximal wall area percentage, the complexity of the airways (airway fractal dimension), and the parenchyma (exponent D) crosssectionally (n = 97). In analysis 2, we evaluated the impact of circulating YKL-40 levels on forced expiratory volume in 1 second (FEV1) decline longitudinally for a 5-year follow-up (n = 103). Results: Circulating YKL-40 levels were significantly associated with proximal wall area percentage and airway fractal dimension (r = 0.25, P = .01; r = -0.22, P = .04, respectively), but not with exponent D. The mean annual change in FEV1 was -33.7 (+/- 23.3) mL/y, and the circulating YKL-40 level was a significant independent factor associated with annual FEV1 decline (beta = -0.24, P =.02), even after controlling for exponent D (beta = -0.26, P = .01). Conclusion: These results provide further evidence for the association of YKL-40 with the pathogenesis of airway remodeling in severe asthma. (C) 2022 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN
1081-1206
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.anai.2022.03.016