Glucagon-Like Peptide-1 Is Involved in the Thermic Effects of Dietary Proteins in Male Rodents

Ochiai, Keita; Muto, Asuka; Seok, Bong Soo et al.

Endocrinology, 2023, 164(6), bqad068

Permalink : https://hdl.handle.net/2115/90084

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/90084
タイトル
Glucagon-Like Peptide-1 Is Involved in the Thermic Effects of Dietary Proteins in Male Rodents
著者
Ochiai, Keita ; Muto, Asuka ; Seok, Bong Soo ; Doi, Yuta ; Iwasaki, Yusaku ; Okamatsu-Ogura, Yuko ; Drucker, Daniel J. ; Hira, Tohru
著者名
Ochiai, Keita
著者名
Muto, Asuka
著者名
Seok, Bong Soo
著者名
Doi, Yuta
著者名
Iwasaki, Yusaku
e-Rad_Researcher
90527178
著者名
Okamatsu-Ogura, Yuko
著者名
Drucker, Daniel J.
e-Rad_Researcher
10396301
著者名
Hira, Tohru
言語
英語
キーワード
gastrointestinal hormone
glucagon-like peptide-1
dietary protein
thermic effect
diet-induced thermogenesis
発行日
2023-05-04
出版者
Endocrine Society
収録物名
Endocrinology
巻(号)
164(6)
ページ
bqad068
抄録
Protein intake potently increases body temperature and energy expenditure, but the underlying mechanism thereof remains incompletely understood. Simultaneously, protein intake potently stimulates glucagon-like peptide-1 (GLP-1) secretion. Here, we examined the involvement of GLP-1 in the thermic effects of dietary proteins in rodents by measuring rectal temperature and energy expenditure and modulating GLP-1 signaling. Rectal temperature of rats or mice fasted for 4 or 5 hours were measured using a thermocouple thermometer before and after an oral administration of nutrients. Oxygen consumption after oral protein administration was also measured in rats. Rectal temperature measurements in rats confirmed an increase in core body temperature after refeeding, and the thermic effect of the oral administration of protein was greater than that of a representative carbohydrate or lipid. Among the five dietary proteins examined (casein, whey, rice, egg, and soy), soy protein had the highest thermic effect. The thermic effect of soy protein was also demonstrated by increased oxygen consumption. Studies using a nonselective beta-adrenergic receptor antagonist and thermal camera suggested that brown adipose tissue did not contribute to soy protein-induced increase in rectal temperature. Furthermore, the thermic effect of soy protein was completely abolished by antagonism and knockout of the GLP-1 receptor, yet potentiated via augmentation of intact GLP-1 levels through inhibition of dipeptidyl peptidase-4 activity. These results indicate that GLP-1 signaling is essential for the thermic effects of dietary proteins in rats and mice, and extend the metabolic actions of GLP-1 ensuing from nutrient ingestion to encompass the thermic response to ingested protein.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0013-7227
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1210/endocr/bqad068