Nostosin G and Spiroidesin B from the Cyanobacterium Dolichospermum sp. NIES-1697

Phan, Chin-Soon; Mehjabin, Jakia Jerin; Anas, Andrea Roxanne J.; Hayasaka, Masahiro; Onoki, Reiko; Wang, Juting; Umezawa, Taiki; Washio, Kenji; Morikawa, Masaaki; Okino, Tatsufumi

Nostosin G and Spiroidesin B from the Cyanobacterium Dolichospermum sp. NIES-1697

Phan, Chin-Soon; Mehjabin, Jakia Jerin; Anas, Andrea Roxanne J. et al.

Journal of Natural Products, 2022, 85(8), 2000-2005

Permalink : https://hdl.handle.net/2115/90284

このアイテムのアクセス数:425件（2026-01-23 23:35 集計）

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Nat.Prod.J_v.85 n.8(2022)	pdf	509 KB	210
np2c00382_si_001-1	pdf	1.38 MB	111	Supporting Information

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アクセス権	open access
URI	https://hdl.handle.net/2115/90284
タイトル	Nostosin G and Spiroidesin B from the Cyanobacterium Dolichospermum sp. NIES-1697
著者	Phan, Chin-Soon ; Mehjabin, Jakia Jerin ; Anas, Andrea Roxanne J. ; Hayasaka, Masahiro ; Onoki, Reiko ; Wang, Juting ; Umezawa, Taiki ; Washio, Kenji ; Morikawa, Masaaki ; Okino, Tatsufumi
著者名 Phan, Chin-Soon
著者名 Mehjabin, Jakia Jerin
著者名 Anas, Andrea Roxanne J.
著者名 Hayasaka, Masahiro
著者名 Onoki, Reiko
著者名 Wang, Juting
e-Rad_Researcher 20503618 著者名 Umezawa, Taiki
e-Rad_Researcher 50241302 著者名 Washio, Kenji
e-Rad_Researcher 20230104 著者名 Morikawa, Masaaki
e-Rad_Researcher 30280910 著者名 Okino, Tatsufumi
言語	英語
発行日	2022-08-10
出版者	American Chemical Society
収録物名	Journal of Natural Products
巻(号)	85(8)
ページ	2000-2005
抄録	Chemical investigation of the cyanobacterium Dolichospermum sp. NIES-1697 afforded nostosin G (1), a linear tripeptide, spiroidesin B (2), and two known compounds, anabaenopeptins I (3) and J (4). Planar structures and absolute configurations for 1 and 2 were determined by 2D NMR, HRMS, Marfey's methodology, chiral-phase HPLC, and enzymatic degradation. Nostosin G (1) is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal, with potent trypsin inhibitory properties. The biosynthetic gene clusters for nostosin G (1) and spiroidesin B (2) were investigated based on the genome sequence of Dolichospermum sp. NIES-1697.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/full/10.1021/acs.jnatprod.2c00382.
PISSN	0163-3864
EISSN	1520-6025
NCID	AA00258639
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.jnatprod.2c00382