Aberrant functional connectivity between anterior cingulate cortex and left insula in association with therapeutic response to biologics in inflammatory arthritis

Abe, Nobuya; Fujieda, Yuichiro; Tha, Khin K.; Narita, Hisashi; Aso, Kuniyuki; Karino, Kohei; Kanda, Masatoshi; Kono, Michihito; Kato, Masaru; Amengual, Olga; Atsumi, Tatsuya

Aberrant functional connectivity between anterior cingulate cortex and left insula in association with therapeutic response to biologics in inflammatory arthritis

Abe, Nobuya; Fujieda, Yuichiro; Tha, Khin K. et al.

Seminars in arthritis and rheumatism, 2022, 55, 151994

Permalink : https://hdl.handle.net/2115/90291

このアイテムのアクセス数:521件（2026-01-18 22:48 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数
SAR 55 151994	pdf	1.93 MB	201
Graphical abstrac	tif	1.57 MB	45
Supplementary materials	docx	7.48 MB	91

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/90291
タイトル	Aberrant functional connectivity between anterior cingulate cortex and left insula in association with therapeutic response to biologics in inflammatory arthritis
著者	Abe, Nobuya ; Fujieda, Yuichiro ; Tha, Khin K. ; Narita, Hisashi ; Aso, Kuniyuki ; Karino, Kohei ; Kanda, Masatoshi ; Kono, Michihito ; Kato, Masaru ; Amengual, Olga ; Atsumi, Tatsuya
著者名 Abe, Nobuya
e-Rad_Researcher 70790872 著者名 Fujieda, Yuichiro
著者名 Tha, Khin K.
著者名 Narita, Hisashi
著者名 Aso, Kuniyuki
著者名 Karino, Kohei
著者名 Kanda, Masatoshi
著者名 Kono, Michihito
著者名 Kato, Masaru
e-Rad_Researcher 10636939 著者名 Amengual, Olga
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	Resting-state functional magnetic resonance imaging
	Neuroimaging
	Rheumatoid arthritis
	Spondyloarthritis
	Functional connectivity
	Patient reported outcome
発行日	2022-08
出版者	Elsevier
収録物名	Seminars in arthritis and rheumatism
巻(号)	55
ページ	151994
抄録	Background: Brain activity is reported to be associated with individual pain susceptibility and inflammatory status, possibly contributing to disease activity assessment in inflammatory arthritis (IA) including rheumatoid arthritis (RA) and spondyloarthritis (SpA). However, what alteration of brain function associated with disease activity and therapeutic effectiveness in IA remains unclear. We aimed to identify the alterations of brain functional connectivity (FC) shared in both RA and SpA, and evaluate its relationship to anti-rheumatic treatment response using functional magnetic resonance imaging (MRI). Patients and methods: Structural and resting-state functional MRI data were acquired from patients with IA, patients with osteoarthritis (OA) and heathy controls (HCs). Two datasets were adopted to derive (51 IA, 56 OA, and 17 HCs) and validate (31 IA) the observations. 33 IA patients in the derivation dataset and all the patients in validation dataset required biological treatment and were clinically evaluated before and after therapy. Via whole-brain pair-wise FC analyses, we analyzed IA-specific FC measures relevant to therapeutic response to biologics. Results: The value of FC between left insular cortex (IC) and anterior cingulate cortex (ACC) was significantly low in IA patients compared with OA patients and HCs. We demonstrated that the FC between left anterior long insular gyrus as a subdivision of IC and ACC was significantly associated with therapeutic response to biologics regarding the improvement of patients' global assessment (PGA) in both derivation and validation datasets. Conclusion: Disease-specific resting-state FC provides a means to assess the therapeutic improvement of PGA and would be a clinical decision-making tool with predictability for treatment response in both RA and SpA. (c) 2022 Elsevier Inc. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0049-0172
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.semarthrit.2022.151994